Quality of life in patients with narcolepsy: A WHOQOL-Bref study

Division of Clinical Neurology, Hospital das Clinicas, Medical School, University of Sao Paulo, Sao Paulo, SP, Brazil.
Arquivos de Neuro-Psiquiatria (Impact Factor: 0.84). 06/2008; 66(2A):163-7. DOI: 10.1590/S0004-282X2008000200004
Source: PubMed


To evaluate the perception of Quality of Life (QL) in Brazilian patients with narcolepsy.
40 adult patients aged between 20 and 72 years (mean=41.55; SD=14.50); (28 F; 12M), with the diagnosis of chronic narcolepsy were followed up at the outpatient clinic (Patient Group). The Control Group was composed of 40 adults. The instrument utilized was the World Health Organization Quality of Life (WHOQOL-BREF).
The two groups were homogeneous and no difference was found with regards to age, sex, and demographic characteristics. The perception of QL in physical, psychological and social domains showed lower scores in those patients with narcolepsy than in the control group (p<0.05). Concerning physical domain, all the aspects evaluated were significantly impaired, in patient group, including sleep satisfaction (p<0.001); energy for daily activities (p=0.039); capacity to perform activities (p=0.001); and capacity to work (p=0.001).
The perception of QL showed severe impairment in patients with narcolepsy for physical, psychological and social domains.

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    • "These patients experience excessive daytime sleepiness with unexpected irresistible sleep episodes, and this domain of health status appears frequently as the most affected [5] [10]. Several investigators report that these clinical symptoms may greatly disrupt social, educational, and professional development, and impair quality of life [7] [9] [11] [26]. Moreover , the lower sleep quality and quantity that narcoleptics experience may lead to the feeling of physical tiredness, causing reduced energy and vitality, with repercussions on the perception of general heath. "
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    ABSTRACT: To evaluate the perception of health-related quality of life (HRQoL) in Portuguese patients with narcolepsy, and to compare the results to normative data. Fifty-one narcoleptic adults (26M, 25F), aged between 18 and 80 years (mean=43.35, SD=15.32), were included in the final analysis of a multicentric cross-sectional study. The Medical Outcome Study--36 Item Short-Form Survey (SF-36) was used to assess quality of life, and the Beck Depression Inventory (BDI) was used for self-assessment of depression. Several HRQoL domains were significantly lower than National surveys, except physical function and bodily pain (p between 0.000 and 0.006). SF-36 presented the lowest score in vitality (39.93). Deterioration was significantly higher in role physical (p=0.006), vitality (p=0.011), and mental health (p=0.008) in women, and in physical function (p=0.003) and bodily pain (p=0.045) in elderly subjects. Those with higher literacy had better physical function (p=0.046). HRQoL is significantly deteriorated in narcoleptics, affecting all dimensions (except physical function and bodily pain) when compared with the general Portuguese population. The results are consistent with studies of narcolepsy in other countries in demonstrating the profound impact of this disorder on quality of life.
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