Bailey MD, Sinnott LT, Mutti DO. Ciliary body thickness and refractive error in children

Ohio State University College of Optometry, Columbus, Ohio, USA.
Investigative ophthalmology & visual science (Impact Factor: 3.4). 06/2008; 49(10):4353-60. DOI: 10.1167/iovs.08-2008
Source: PubMed


To determine whether ciliary body thickness (CBT) is related to refractive error in school-age children.
Fifty-three children, 8 to 15 years of age, were recruited. CBT was measured from anterior segment OCT images (Visante; Carl Zeiss Meditec, Inc., Dublin, CA) at 1 (CBT1), 2 (CBT2) and 3 (CBT3) mm posterior to the scleral spur. Cycloplegic refractive error was measured with an autorefractor, and axial length was measured with an optical biometer. Multilevel regression models determined the relationship between CBT measurements and refractive error or axial length. A Bland-Altman analysis was used to assess the between-visit repeatability of the ciliary body measurements.
The between-visits coefficients of repeatability for CBT1, -2, and -3 were 148.04, 165.68, and 110.90, respectively. Thicker measurements at CBT2 (r = -0.29, P = 0.03) and CBT3 (r = -0.38, P = 0.005) were associated with increasingly myopic refractive errors (multilevel model: P < 0.001). Thicker measurements at CBT2 (r = 0.40, P = 0.003) and CBT3 (r = 0.51, P < 0.001) were associated with longer axial lengths (multilevel model: P < 0.001).
Thicker ciliary body measurements were associated with myopia and a longer axial length. Future studies should determine whether this relationship is also present in animal models of myopia and determine the temporal relationship between thickening of the ciliary muscle and the onset of myopia.

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Available from: Melissa D Bailey, Nov 13, 2015
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    • "In this case, ultrasound biomicroscopy is still the preferred imaging method for ciliary body pathologies. Melissa et al. reported that measurement of ciliary body thickness at 1, 2, and 3 mm posterior to the scleral spur in children but deciding where the lower border of ciliary body under the iris was complicated[3,46] "

    Full-text · Chapter · May 2014
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    • "The conjugated artifact is common in SD-OCT, unless phase shift method is used [20,36]. The conjugate artifact is not in time-domain OCT [35,37] or swept light source OCT [18]. The details of the conjugated artifact of the iris and its relation to the placement of the delay line have been reported in some published work [20,38]. "
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    ABSTRACT: We demonstrated a novel approach of imaging the anterior segment including the ciliary muscle using combined and synchronized two spectral domain optical coherence tomography devices (SD-OCT). In one SD-OCT, a Complementary Metal-Oxide-Semiconductor Transistor (CMOS) camera and an alternating reference arm was used to image the anterior segment from the cornea to the lens. Another SD-OCT for imaging the ciliary muscle was equipped with a light source with a center wavelength of 1,310 nm and a bandwidth of 75 nm. Repeated measurements were performed under relaxed and 4.00 D accommodative stimulus states in six eyes from 6 subjects. We also imaged dynamic changes in the anterior segment in one eye during accommodation. The biometry of the anterior segment and the ciliary muscle was obtained. The combined system appeared to be capable to simultaneously real-time image the biometry of the anterior segment, including the ciliary muscle, in vivo during accommodation.
    Full-text · Article · Mar 2013 · Biomedical Optics Express
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    ABSTRACT: This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without proper acknowledgement.
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