Article

Bailey MD, Sinnott LT, Mutti DO. Ciliary body thickness and refractive error in children

Ohio State University College of Optometry, Columbus, Ohio, USA.
Investigative ophthalmology & visual science (Impact Factor: 3.4). 06/2008; 49(10):4353-60. DOI: 10.1167/iovs.08-2008
Source: PubMed

ABSTRACT

To determine whether ciliary body thickness (CBT) is related to refractive error in school-age children.
Fifty-three children, 8 to 15 years of age, were recruited. CBT was measured from anterior segment OCT images (Visante; Carl Zeiss Meditec, Inc., Dublin, CA) at 1 (CBT1), 2 (CBT2) and 3 (CBT3) mm posterior to the scleral spur. Cycloplegic refractive error was measured with an autorefractor, and axial length was measured with an optical biometer. Multilevel regression models determined the relationship between CBT measurements and refractive error or axial length. A Bland-Altman analysis was used to assess the between-visit repeatability of the ciliary body measurements.
The between-visits coefficients of repeatability for CBT1, -2, and -3 were 148.04, 165.68, and 110.90, respectively. Thicker measurements at CBT2 (r = -0.29, P = 0.03) and CBT3 (r = -0.38, P = 0.005) were associated with increasingly myopic refractive errors (multilevel model: P < 0.001). Thicker measurements at CBT2 (r = 0.40, P = 0.003) and CBT3 (r = 0.51, P < 0.001) were associated with longer axial lengths (multilevel model: P < 0.001).
Thicker ciliary body measurements were associated with myopia and a longer axial length. Future studies should determine whether this relationship is also present in animal models of myopia and determine the temporal relationship between thickening of the ciliary muscle and the onset of myopia.

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Available from: Melissa D Bailey, Nov 13, 2015
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    • "In this case, ultrasound biomicroscopy is still the preferred imaging method for ciliary body pathologies. Melissa et al. reported that measurement of ciliary body thickness at 1, 2, and 3 mm posterior to the scleral spur in children but deciding where the lower border of ciliary body under the iris was complicated[3,46] "

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    ABSTRACT: This copy of the thesis has been supplied on condition that anyone who consults it is understood to recognise that its copyright rests with its author and that no quotation from the thesis and no information derived from it may be published without proper acknowledgement.
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