Embryonal rhabdomyosarcoma of the chest wall: A case report and review of the literature

ArticleinIndian Journal of Pathology and Microbiology 51(2):274-6 · May 2008with6 Reads
Impact Factor: 0.47 · DOI: 10.4103/0377-4929.41694 · Source: PubMed

    Abstract

    Embryonal rhabdomyosarcoma is a soft-tissue sarcoma which has a predilection for the head and neck area, genitourinary tract and the extremities. We report a rare case of embryonal rhabdomyosarcoma of the chest wall in an 8-year-old girl, presenting as a destructive tumor in the rib and clinically and radiologically mimicking Ewing's sarcoma. Histopathological examination showed a small round cell tumor. Immunohistochemically, the positivity for muscle markers desmin and myogenin in the tumor cells proved to be useful for making a definitive diagnosis of embryonal rhabdomyosarcoma. Cytogenetic analysis revealed a high level of aneuploidy in the tumor cells, with double-minutes and additional chromosomal structural aberrations. The patient is responding well to chemotherapy.