Volumetric navigators for prospective motion correction and selective reacquisition in neuroanatomical MRI

Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Magnetic Resonance in Medicine (Impact Factor: 3.57). 12/2011; 68(2):389-99. DOI: 10.1002/mrm.23228
Source: PubMed


We introduce a novel method of prospectively compensating for subject motion in neuroanatomical imaging. Short three-dimensional echo-planar imaging volumetric navigators are embedded in a long three-dimensional sequence, and the resulting image volumes are registered to provide an estimate of the subject's location in the scanner at a cost of less than 500 ms, ~ 1% change in contrast, and ~3% change in intensity. This time fits well into the existing gaps in sequences routinely used for neuroimaging, thus giving a motion-corrected sequence with no extra time required. We also demonstrate motion-driven selective reacquisition of k-space to further compensate for subject motion. We perform multiple validation experiments to evaluate accuracy, navigator impact on tissue intensity/contrast, and the improvement in final output. The complete system operates without adding additional hardware to the scanner and requires no external calibration, making it suitable for high-throughput environments.

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    • "However, it is likely that individuals with ASD who exhibit more severe symptoms would also find it harder to remain still in the MRI scanner for a long period of time and thus there may be a selection bias in our data. Future research should employ real-time prospective motion correction (PMC) techniques (e.g.,888990) during the sMRI scan. The use of PMC techniques can also prevent the risk of using sedation, is more likely to be approved by most IRB for research purpose, and may be a better option than sedation for future sMRI research that aims at minimizing head motion confounds[91]. "
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    ABSTRACT: Individuals with autism spectrum disorder (ASD) have been characterized by altered cerebral cortical structures; however, the field has yet to identify consistent markers and prior studies have included mostly adolescents and adults. While there are multiple cortical morphological measures, including cortical thickness, surface area, cortical volume, and cortical gyrification, few single studies have examined all these measures. The current study analyzed all of the four measures and focused on pre-adolescent children with ASD. We employed the FreeSurfer pipeline to examine surface-based morphometry in 60 high-functioning boys with ASD (mean age = 8.35 years, range = 4–12 years) and 41 gender-, age-, and IQ-matched typically developing (TD) peers (mean age = 8.83 years), while testing for age-by-diagnosis interaction and between-group differences. During childhood and in specific regions, ASD participants exhibited a lack of normative age-related cortical thinning and volumetric reduction and an abnormal age-related increase in gyrification. Regarding surface area, ASD and TD exhibited statistically comparable age-related development during childhood. Across childhood, ASD relative to TD participants tended to have higher mean levels of gyrification in specific regions. Within ASD, those with higher Social Responsiveness Scale total raw scores tended to have greater age-related increase in gyrification in specific regions during childhood. ASD is characterized by cortical neuroanatomical abnormalities that are age-, measure-, statistical model-, and region-dependent. The current study is the first to examine the development of all four cortical measures in one of the largest pre-adolescent samples. Strikingly, Neurosynth-based quantitative reverse inference of the surviving clusters suggests that many of the regions identified above are related to social perception, language, self-referential, and action observation networks—those frequently found to be functionally altered in individuals with ASD. The comprehensive, multilevel analyses across a wide range of cortical measures help fill a knowledge gap and present a complex but rich picture of neuroanatomical developmental differences in children with ASD.
    Full-text · Article · Dec 2016 · Molecular Autism
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    • "i - shot , segmented EPI to motion and B 0 changes across segments include direct alignment of phase between segments in post - processing , although typically these methods require extra information or additional scans [ Hoge et al . , 2010 ; Chen et al . , 2013 ] . Bulk , rigid head motion could potentially be addressed by either image - based [ Tisdall et al . , 2012 ] or external sensor - based [ Zaitsev et al . , 2006 ; Schulz et al . , 2012 ] motion tracking along with either real - time feedback to the gradient system or a model for how the motion impacts the information acquired across the multiple , interleaved segments . However , independent motion ( e . g . , of the eyes ) during ACS acquis"
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    ABSTRACT: To reduce the sensitivity of echo-planar imaging (EPI) auto-calibration signal (ACS) data to patient respiration and motion to improve the image quality and temporal signal-to-noise ratio (tSNR) of accelerated EPI time-series data. ACS data for accelerated EPI are generally acquired using segmented, multishot EPI to distortion-match the ACS and time-series data. The ACS data are, therefore, typically collected over multiple TR periods, leading to increased vulnerability to motion and dynamic B0 changes. The fast low-angle excitation echo-planar technique (FLEET) is adopted to reorder the ACS segments so that segments within any given slice are acquired consecutively in time, thereby acquiring ACS data for each slice as rapidly as possible. Subject breathhold and motion phantom experiments demonstrate that artifacts in the ACS data reduce tSNR and produce tSNR discontinuities across slices in the accelerated EPI time-series data. Accelerated EPI data reconstructed using FLEET-ACS exhibit improved tSNR and increased tSNR continuity across slices. Additionally, image quality is improved dramatically when bulk motion occurs during the ACS acquisition. FLEET-ACS provides reduced respiration and motion sensitivity in accelerated EPI, which yields higher tSNR and image quality. Benefits are demonstrated in both conventional-resolution 3T and high-resolution 7T EPI time-series data. Magn Reson Med, 2015. © 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
    Full-text · Article · Mar 2015 · Magnetic Resonance in Medicine
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    • "A Multi-Echo MPRAGE (MEMPR) with motion correction, developed at the Massachusetts General Hospital (MGH, Boston), was employed [70,71]. This sequence has the advantage of combining the properties of the classical MPRAGE sequence, which has high contrast aiding cortical segmentation, with Multi-Echo FLASH, which improves segmentation of subcortical regions. "
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    Full-text · Article · May 2014 · BMC Psychiatry
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