Antimycobacterial activities of 5-alkyl (or halo)-3 '-substituted pyrimidine nucleoside analogs

ArticleinBioorganic & medicinal chemistry letters 22(2):1091-4 · December 2011with11 Reads
Impact Factor: 2.42 · DOI: 10.1016/j.bmcl.2011.11.114 · Source: PubMed


    Several 5-alkyl (or halo)-3'-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium. Among these compounds, 3'-azido-5-ethyl-2',3'-dideoxyuridine (3) was found to have significant antimycobacterial activities against M. bovis (MIC(50)=1μg/mL), M. tuberculosis (MIC(50)=10μg/mL) and M. avium (MIC(50)=10μg/mL).