Synthesis and cytotoxicity of O,O '-dialkyl {[2-(substituted phenoxy) acetamido](substituted phenyl)methyl}phosphonates

ArticleinEuropean Journal of Medicinal Chemistry 48:379-84 · December 2011with1 Read
Impact Factor: 3.45 · DOI: 10.1016/j.ejmech.2011.12.014 · Source: PubMed

    Abstract

    A series of O,O'-dialkyl {[2-(substituted phenoxy)acetamido](substituted phenyl)methyl}phosphonates was synthesized and their cytotoxic activities were tested against various human tumor cell lines. Some compounds (5q, 5r, 5s, 5w, 5x and 5y) showed relatively high cytotoxicity. Especially, compounds 5x and 5q exhibited the best cytotoxicity against KB and CNE2 cells with IC(50) 7.1 and 11.4 μM, respectively. Their inhibitory activities against KB and CNE2 cells were even higher than that of fluorouracil.