Canine Hip Dysplasia: Reviewing the Evidence for Nonsurgical Management

Seattle Veterinary Specialists, Kirkland, WA.
Veterinary Surgery (Impact Factor: 1.04). 12/2011; 41(1). DOI: 10.1111/j.1532-950X.2011.00928.x
Source: PubMed


OBJECTIVE: To systematically review the evidence available for nonsurgical management of hip dysplasia (HD). STUDY DESIGN: Literature review. METHODS: Databases (Pubmed, Veterinary Information Network) were searched for clinical studies on nonsurgical management of HD in dogs. The evidence in each study was reviewed and assigned a score (I-IV) based on previously reported levels of evidence. RESULTS: Fourteen articles were identified that met the inclusion criteria, including 3 Level IV, 4 Level III, and 7 Level II studies. Methods of nonsurgical management reviewed included: activity restrictions, weight management, acupuncture, modulation of joint disease by polysulfated glycosaminoglycans, mesenchymal stem cell therapy, and extra corporeal shock wave therapy. CONCLUSION: Weight management is an effective and important component of managing dogs with HD and associated osteoarthritis. Techniques that modulate the progression of joint disease may also be beneficial for treating dogs with HD. Further studies are needed to investigate other methods of managing HD such as hydrotherapy and physical rehabilitation.

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    • "Mesenchymal stem cell (MSC) therapy is a newly developing therapeutic approach in OA that has proven useful in cartilage repair in a variety of animal models (Murphy et al., 2003; Black et al., 2007, 2008; Chong et al., 2007; Koga et al., 2008; Khan et al., 2010; Mokbel et al., 2011a, 2011b; Guercio et al., 2012; Jorgensen and Noel, 2012; Kirkby and Lewis, 2012). Bone marrow-derived MSCs hold particular promise for tissue repair because of their ability to engraft into tissues and differentiate into the target tissue cell type, including fibroblasts, osteocytes, adipocytes, chondrocytes and myocytes (Pittenger et al., 1999; Chamberlain et al., 2007). "
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    No preview · Article · Sep 2014 · The Veterinary Journal
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    • "In this study, we propose the use of acupuncture points for stem cell therapy. The practice of acupuncture is very old in human medicine and is also a well-described veterinary procedure [14] [15], although some controversial opinions have been expressed [16]. Acupuncture has been used to treat dogs and cats for around 10 years, mainly for musculoskeletal problems [14], low back pain [17], knee osteoarthritis [18], tension-type headache, and migraine [19] [20]. "
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    ABSTRACT: Stem cells isolated from adipose tissue show great therapeutic potential in veterinary medicine, but some points such as the use of fresh or cultured cells and route of administration need better knowledge. This study aimed to evaluate the effect of autologous stromal vascular fraction (SVF, n = 4 ) or allogeneic cultured adipose-derived stem cells (ASCs, n = 5 ) injected into acupuncture points in dogs with hip dysplasia and weak response to drug therapy. Canine ASCs have proliferation and differentiation potential similar to ASCs from other species. After the first week of treatment, clinical evaluation showed marked improvement compared with baseline results in all patients treated with autologous SVF and three of the dogs treated with allogeneic ASCs. On days 15 and 30, all dogs showed improvement in range of motion, lameness at trot, and pain on manipulation of the joints, except for one ASC-treated patient. Positive results were more clearly seen in the SVF-treated group. These results show that autologous SVF or allogeneic ASCs can be safely used in acupoint injection for treating hip dysplasia in dogs and represent an important therapeutic alternative for this type of pathology. Further studies are necessary to assess a possible advantage of SVF cells in treating joint diseases.
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    No preview · Chapter · Jun 2013
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