As a nonbinary public health advocate , therapist, and researcher and as a parent of a trans girl, I am both moved and troubled by Rider et al.'s article in this issue of AJPH (p. 499). I want to thank and congratulate the authors for studying an extremely important yet underexa-mined topic in this put-at-risk population , and I thank AJPH for shedding light on this public health issue. As a sex work rights activist, it is important for me to clarify that sex trading among youths is psychologically, legally, and morally distinct from sex trading among adults. As such, trading sex as youths is, by nature, exploitative. Trading sex is an extreme risk factor for mental health challenges, including suicide and self-harm among youths, and especially among transgender and gender diverse (TGD) youths. Approximately 6% of TGD 9th and 11th graders report having traded sex in their relatively short lifetimes. More than three quarters of TGD youths who traded sex attempted to end their lives by suicide. This is a public health catastrophe. Think about Layla, a 16-year-old Black trans girl, who trades sex to buy food and sleep in someone's place to spend the freezing winter nights indoors. Consider the multiple systems that actively pushed Layla to trade sex: the rejecting family; the overburdened school staff who do not understand why Layla is struggling academically; the lack of community support for TGD youths due to lack of funding by the city and state; and the transphobic laws and policies, along with pervasive negative attitudes toward TGD individuals in the United States. Sex trading among youths is a result of the unjust lack of support, resources , and programs designed to empower youths, especially TGD youths. Put differently, sex trading among TGD youths is an indicator of failure at multiple levels, including the family, school, community, city, state, and federal systems. Clearly, there is a dire need for multilevel public health interventions and programs addressing sex trading among youths, especially among TGD youths. In fact, we need interventions far earlier in the trajectory into sex trading. Tangible intervention recommendations to address sex trading among TGD youths, along with its antecedents and consequences across multiple levels are included (Box 1). To continuously inform and refine multilevel intervention programs, further research on TGD youths who trade sex is warranted. First, investigating the individual, interpersonal, and institutional risk factors for sex trading is critical to further elucidate trajecto-ries into sex trading and to identify more intervention targets to eliminate sex trading among TGD youths. Second , given the alarming rates of suicide attempts and self-harm among TGD youths who trade sex, examining famil-ial, school, community, and other structural resilience factors is particularly needed. Third, applying syndemics theory to research about sex trading among TGD youths may prove beneficial because sex trading often coexists with other syndemic conditions, such as housing instability, polysubstance use, childhood trauma, and intimate partner violence. 11 Fourth, to protect TGD youths, future studies would benefit from inquiring with whom they traded sex and for what purposes. Last, given that most TGD youths who traded sex identified as LGBQ1 and of color, employing an intersectional framework in future research is essential to identifying the unique needs of TGD youths who trade sex.