The Netherlands study of depression in older persons (NESDO); A prospective cohort study

Department Psychiatry/EMGO Institute for Health and Care Research, VU University Medical Center/GGZinGeest, Amsterdam, The Netherlands. .
BMC Research Notes 12/2011; 4(1):524. DOI: 10.1186/1756-0500-4-524
Source: PubMed


To study late-life depression and its unfavourable course and co morbidities in The Netherlands.
We designed the Netherlands Study of Depression in Older Persons (NESDO), a multi-site naturalistic prospective cohort study which makes it possible to examine the determinants, the course and the consequences of depressive disorders in older persons over a period of six years, and to compare these with those of depression earlier in adulthood.
From 2007 until 2010, the NESDO consortium has recruited 510 depressed and non depressed older persons (≥ 60 years) at 5 locations throughout the Netherlands. Depressed persons were recruited from both mental health care institutes and general practices in order to include persons with late-life depression in various developmental and severity stages. Non-depressed persons were recruited from general practices. The baseline assessment included written questionnaires, interviews, a medical examination, cognitive tests and collection of blood and saliva samples. Information was gathered about mental health outcomes and demographic, psychosocial, biological, cognitive and genetic determinants. The baseline NESDO sample consists of 378 depressed (according to DSM-IV criteria) and 132 non-depressed persons aged 60 through 93 years. 95% had a major depression and 26.5% had dysthymia. Mean age of onset of the depressive disorder was around 49 year. For 33.1% of the depressed persons it was their first episode. 41.0% of the depressed persons had a co morbid anxiety disorder. Follow up assessments are currently going on with 6 monthly written questionnaires and face-to-face interviews after 2 and 6 years.
The NESDO sample offers the opportunity to study the neurobiological, psychosocial and physical determinants of depression and its long-term course in older persons. Since largely similar measures were used as in the Netherlands Study of Depression and Anxiety (NESDA; age range 18-65 years), data can be pooled thus creating a large longitudinal database of clinically depressed persons with adequate power and a large set of neurobiological, psychosocial and physical variables from both younger and older depressed persons.

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    • "The current study used data from the Netherlands Study of Depression in Older Persons (NESDO; age Z60 years), a multi-site prospective cohort study designed to examine the course and consequences of late-life depression (Comijs et al., 2011). Recruitment took place in five regions in the Netherlands from mental health care institutes, ambulatory and clinical mental health care, and general practices. "
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    ABSTRACT: Although depression and loneliness are common among older adults, the role of loneliness on the prognosis of late-life depression has not yet been determined. Therefore, we examined the association between loneliness and the course of depression. We conducted a 2-year follow-up study of a cohort from the Netherlands Study of Depression in Older Persons (NESDO). This included Dutch adults aged 60-90 years with a diagnosis of major depression, dysthymia, or minor depression according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. We performed regression analyses to determine associations between loneliness at baseline and both severity and remission of depression at follow-up. We controlled for potential confounders and performed multiple imputations to account for missing data. Of the 285 respondents, 48% were still depressed after 2 years. Loneliness was independently associated with more severe depressive symptoms at follow-up (beta 0.61; 95% CI 0.12-1.11). Very severe loneliness was negatively associated with remission after 2 years compared with no loneliness (OR 0.25; 95% CI 0.08-0.80). Despite using multiple imputation, the large proportion of missing values probably reduces the study's precision. Generalizability to the general population may be limited by the overrepresentation of ambulatory patients with possibly more persistent forms of depression. In this cohort, the prognosis of late-life depression was adversely affected by loneliness. Health care providers should seek to evaluate the degree of loneliness to obtain a more reliable assessment of the prognosis of late-life depression. Copyright © 2015 Elsevier B.V. All rights reserved.
    No preview · Article · Jun 2015 · Journal of Affective Disorders
    • "Also, local feasibility certificates were provided by each participating institution. For more details on recruitment and research procedures of the NESDO study, see [11] "
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    ABSTRACT: Late-life depression and pain more often co-occur than can be explained by chance. Determinants of pain in late-life depression are unknown, even though knowledge on possible determinants of pain in depression is important for clinical practice. Therefore, the objectives of the present study were 1) to describe pain characteristics of depressed older adults and a non-depressed comparison group and 2) to explore physical, lifestyle, psychological and social determinants of acute and chronic pain intensity, disability and multisite pain in depressed older adults. Data of the NESDO cohort, consisting of 378 depressed persons, diagnosed according to DSM-IV criteria, and 132 non-depressed persons of 60 years and older, were used in a cross-sectional design. Pain characteristics were measured by the Chronic Graded Pain Scale. Multiple linear regression analyses were performed to explore the contribution of physical, lifestyle, psychological and social determinants to outcomes pain intensity, disability and the number of painlocations. Depressed older adults more often reported chronic pain and experienced their pain as more intense and disabling compared to non-depressed older adults. Adjusted for demographic, physical and lifestyle characteristics, multinominal logistic regression analyses showed increased odds ratios for depression in acute pain ([OR] = 3.010; p = .005) and chronic pain ([OR] = 4.544, p < .001). In addition, linear regression analyses showed acute and chronic pain intensity, disability and multisite pain were associated with several biopsychosocial determinants of which anxiety was most pronounced. Further research could focus on the temporal relationship between anxiety, late-life depression and pain.
    No preview · Article · Jul 2014 · Pain
    • "The NESDO is a longitudinal multi-site naturalistic cohort study aimed at examining the course and consequences of depressive disorders in older persons. The study design of the NESDO is described in detail elsewhere (Comijs et al., 2011). "
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    ABSTRACT: Background Knowledge about characteristics explaining low level of physical activity in late-life depression is needed to develop specific interventions aimed at improving physical health in depressed people above the age of 60. Methods This cross-sectional study used data from the Netherlands Study of Depression in Older Persons (NESDO), a longitudinal multi-site naturalistic cohort study. People aged 60 and over with current depression and a non-depressed comparison group were included, and total amount of PA per week was assessed with the short version of the International Physical Activity Questionnaire (IPAQ). Depression characteristics, socio-demographics, cognitive function, somatic condition, psycho-social, environment and other lifestyle factors were added in a multiple regression analysis. Results Depressed persons >60 y were less physically active in comparison with non-depressed subjects. The difference was determined by somatic condition (especially, functional limitations) and by psychosocial characteristics (especially sense of mastery). Within the depressed subgroup only, a lower degree of physical activity was associated with more functional limitations, being an inpatient, and the use of more medication, but not with the severity of the depression. Limitation This study is based on cross-sectional data, so no conclusions can be drawn regarding causality. Conclusions This study confirms that depression in people over 60 is associated with lower physical activity. Patient characteristics seem more important than the depression diagnosis itself or the severity of depression. Interventions aimed at improving physical activity in depressed persons aged 60 and over should take these characteristics into account.
    No preview · Article · Jun 2014 · Journal of Affective Disorders
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