Probiotic yogurt improves antioxidant status in type 2 diabetic patients

Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition (Impact Factor: 2.93). 11/2011; 28(5):539-43. DOI: 10.1016/j.nut.2011.08.013
Source: PubMed


Oxidative stress plays a major role in the pathogenesis and progression of diabetes. Among various functional foods with an antioxidant effect, probiotic foods have been reported to repress oxidative stress. The objective of this clinical trial was to assess the effects of probiotic and conventional yogurt on blood glucose and antioxidant status in type 2 diabetic patients.
Sixty-four patients with type 2 diabetes mellitus, 30 to 60 y old, were assigned to two groups in this randomized, double-blind, controlled clinical trial. The patients in the intervention group consumed 300 g/d of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 and those in the control group consumed 300 g/d of conventional yogurt for 6 wk. Fasting blood samples, 24-h dietary recalls, and anthropometric measurements were collected at the baseline and at the end of the trial.
Probiotic yogurt significantly decreased fasting blood glucose (P < 0.01) and hemoglobin A1c (P < 0.05) and increased erythrocyte superoxide dismutase and glutathione peroxidase activities and total antioxidant status (P < 0.05) compared with the control group. In addition, the serum malondialdehyde concentration significantly decreased compared with the baseline value in both groups (P < 0.05). No significant changes from baseline were shown in insulin concentration and erythrocyte catalase activity within either group (P > 0.05).
The consumption of probiotic yogurt improved fasting blood glucose and antioxidant status in type 2 diabetic patients. These results suggest that probiotic yogurt is a promising agent for diabetes management.

Download full-text


Available from: Aziz Homayouni, Aug 23, 2014
  • Source
    • "There are reports of the demonstrated antimicrobial activity of organic acids (Ström et al., 2002; De Muynck et al., 2004), probiotic culture supernatants and their ethyl acetate extracts (Lavermicocca et al., 2000). Besides antimicrobial activity, probiotics are also reported to have antioxidant and anti-ageing activities (Ejtahed et al., 2012; Li et al., 2012). The presence of excessive reactive oxygen species (ROS) such as hydroxyl radicals (OH), superoxide anions ( . "

    Full-text · Article · Sep 2015
  • Source
    • "Several studies have also shown that probiotic products could regulate the blood glucose level in diabetic human89. Moreover, L. casei Shirota has been reported to reduce blood glucose level through reducing lipopolysaccharide-binding protein10. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Gut microbiota mediated low-grade inflammation is involved in the onset of type 2 diabetes (T2DM). In this study, we used a high fat sucrose (HFS) diet-induced pre-insulin resistance and a low dose-STZ HFS rat models to study the effect and mechanism of Lactobacillus casei Zhang in protecting against T2DM onset. Hyperglycemia was favorably suppressed by L. casei Zhang treatment. Moreover, the hyperglycemia was connected with type 1 immune response, high plasma bile acids and urine chloride ion loss. This chloride ion loss was significantly prevented by L. casei via upregulating of chloride ion-dependent genes (ClC1-7, GlyRα1, SLC26A3, SLC26A6, GABAAα1, Bestrophin-3 and CFTR). A shift in the caecal microflora, particularly the reduction of bile acid 7α-dehydroxylating bacteria, and fecal bile acid profiles also occurred. These change coincided with organ chloride influx. Thus, we postulate that the prevention of T2DM onset by L. casei Zhang may be via a microbiota-based bile acid-chloride exchange mechanism.
    Full-text · Article · Jul 2014 · Scientific Reports
  • Source
    • "Molecular mechanisms involving the anti-diabetic effects of probiotics are not fully elucidated, but may be related to reduction of oxidative stress, immunomodulation, attenuation of inflammation and modification of the intestinal microbiota (Figure 1) [9]. Furthermore, probiotics have been shown to improve the absorption of antioxidants and reduce post-prandial lipid concentrations, actions directly related to oxidative stress [121]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Diabetes is a condition of multifactorial origin, involving several molecular mechanisms related to the intestinal microbiota for its development. In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1, reducing insulin sensitivity. In type 1 diabetes, the lowered expression of adhesion proteins within the intestinal epithelium favours a greater immune response that may result in destruction of pancreatic beta cells by CD8+ T-lymphocytes, and increased expression of interleukin-17, related to autoimmunity. Research in animal models and humans has hypothesized whether the administration of probiotics may improve the prognosis of diabetes through modulation of gut microbiota. We have shown in this review that a large body of evidence suggests probiotics reduce the inflammatory response and oxidative stress, as well as increase the expression of adhesion proteins within the intestinal epithelium, reducing intestinal permeability. Such effects increase insulin sensitivity and reduce autoimmune response. However, further investigations are required to clarify whether the administration of probiotics can be efficiently used for the prevention and management of diabetes.
    Full-text · Article · Jun 2014 · Nutrition Journal
Show more