Chronic Hepatitis B Virus Infection and Pancreatic Cancer: A Case-control Study in Southern China

Department of Gastrointestinal and Pancreatic Surgery, the First Affiliated Hospital, Sun Yat-Sen University, China.
Asian Pacific journal of cancer prevention: APJCP (Impact Factor: 2.51). 01/2011; 12(6):1405-8.
Source: PubMed


The association of hepatitis B virus (HBV) infection and pancreatic cancer is still controversial. The purpose of this study is to determine whether chronic HBV infection increases the risk.
In this case-control study, there were 1,066 patients recruited, with 533 in the study group and 533 controls, frequency-matched for age and sex. Blood samples were collected to detect hepatitis viral infection.
Compared to 77 patients (14.4%) in the control group, 80 pancreatic cancer patients (15.0%) were seropositive for HBV surface antigen (not statistically significant, P=0.8). The prevalence of HBV e antigen was higher in study group than that of control group (P=0.03). Further analysis indicated that HBeAg was a risk factor for pancreatic cancer (OR=2.935, 95% CI: 1.048-8.220).
In HBV endemic area of China, there appears to be no significant association between chronic HBV infection and pancreatic cancer, but the role of HBeAg needs further exploration.

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Available from: Haoran Li, Jan 06, 2014
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    • "References Country or area Age (years) Study period Study design Control type PaC ascertainment Number of cases Number of control participants a HBV markers HBV detection NOS score Berrington de Gonzalez et al. (2008) Korea 45 + 1992–2005 Cohort NA Cancer registry; death certificates 2194 b 631 172 b HBsAg NS 6 Hassan et al. (2008) USA NS 2000–2007 Case–control P Pathologically 476 879 HBsAg, anti-HBs, anti-HBc ELISA 9 Iloeje et al. (2009) Taiwan 30–65 1991–2007 Cohort NA Cancer registry; death certification; national health insurance profiles 48 22 471 HBsAg, HBeAg c , HBV DNA Radioimmunoassay 9 Tang et al. (2009) USA 18 + 1995–2008 Retrospective cohort NA Cancer registry 101 74 851 HBsAg, anti-HBs, anti-HBc, HBeAg, HBV DNA NS 9 Chang et al. (2009) Taiwan NA NA Case–control P Cytological pathologically 147 1716 HBsAg, anti-HBs, anti-HBc — d — d Hong et al. (2010) Korea NS 2003–2008 Case–control H Histologically (58.1%) 506 1008 HBsAg anti-HBs, HBV DNA ARCHITECT assay 8 Wang et al. (2011) Mainland China NS 1999–2010 Case–control H Discharge diagnoses (histologically) 645 711 HBsAg, anti-HBs, anti-HBc, HBeAg, anti-HBe ELISA 8 Zhu et al. (2011) "
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