Unravelling global genome organization by 3C-seq
The Wistar Institute, Philadelphia, PA, USA.Seminars in Cell and Developmental Biology (Impact Factor: 6.27). 11/2011; 23(2):213-21. DOI: 10.1016/j.semcdb.2011.11.003
Eukaryotic genomes exist in the cell nucleus as an elaborate three-dimensional structure which reflects various nuclear processes such as transcription, DNA replication and repair. Next-generation sequencing (NGS) combined with chromosome conformation capture (3C), referred to as 3C-seq in this article, has recently been applied to the yeast and human genomes, revealing genome-wide views of functional associations among genes and their regulatory elements. Here, we compare the latest genomic approaches such as 3C-seq and ChIA-PET, and provide a condensed overview of how eukaryotic genomes are functionally organized in the nucleus.
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