Nab-paclitaxel in the treatment of metastatic breast cancer: A comprehensive review

Department of Medicine, Division of Hematology/Oncology, Sylvester Comprehensive Cancer Center, University of Miami, Leonard M Miller School of Medicine, 1475 NW 12th Avenue, Miami, FL 33136, USA.
Expert Review of Clinical Pharmacology (Impact Factor: 2.18). 05/2011; 4(3):329-34. DOI: 10.1586/ecp.11.7
Source: PubMed


The novel paclitaxel formulation (nanoparticle albumin-bound [nab] paclitaxel (Abraxane(®)) has recently been approved by the US FDA for treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6 months after adjuvant chemotherapy. Apart from its superior efficacy, as demonstrated in the pivotal Phase III study, less toxicity compared with the traditional solvent-containing paclitaxel (Taxol(®)) seems to contribute to its favorable therapeutic index. While approved as a single agent, nab-paclitaxel may prove more effective in combination with either biologic agents and/or other cytotoxic chemotherapeutic agents, as summarized in this article.

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    • "Ixabepilone, a semi-synthetic epothilone analog, is indicated as a monotherapy for patients with locally advanced or metastatic breast cancer who have failed an anthracycline, a taxane, and capecitabine and in combination with capecitabine for the treatment of metastatic or locally advanced breast cancer after a failure of an anthracycline and a taxane [23] [24] . In a phase 2 single-arm study of ixabepilone monotherapy in patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine, independent radiology facility (IRF)-assessed objective response rate (ORR) in all treated patients (n = 126) was 11.1%, 50% of patients achieved SD, 14.3% had SD for ≥6 months, median PFS was 3.1 months, and median OS was 8.6 months [25] . "

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