Article

Poor Trail Making Test Performance Is Directly Associated with Altered Dual Task Prioritization in the Elderly – Baseline Results from the TREND Study

Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, Tuebingen, Germany.
PLoS ONE (Impact Factor: 3.23). 11/2011; 6(11):e27831. DOI: 10.1371/journal.pone.0027831
Source: PubMed

ABSTRACT

Deterioration of executive functions in the elderly has been associated with impairments in walking performance. This may be caused by limited cognitive flexibility and working memory, but could also be caused by altered prioritization of simultaneously performed tasks. To disentangle these options we investigated the associations between Trail Making Test performance--which specifically measures cognitive flexibility and working memory--and dual task costs, a measure of prioritization.
Out of the TREND study (Tuebinger evaluation of Risk factors for Early detection of Neurodegenerative Disorders), 686 neurodegeneratively healthy, non-demented elderly aged 50 to 80 years were classified according to their Trail Making Test performance (delta TMT; TMT-B minus TMT-A). The subjects performed 20 m walks with habitual and maximum speed. Dual tasking performance was tested with walking at maximum speed, in combination with checking boxes on a clipboard, and subtracting serial 7 s at maximum speeds. As expected, the poor TMT group performed worse when subtracting serial 7 s under single and dual task conditions, and they walked more slowly when simultaneously subtracting serial 7 s, compared to the good TMT performers. In the walking when subtracting serial 7 s condition but not in the other 3 conditions, dual task costs were higher in the poor TMT performers (median 20%; range -6 to 58%) compared to the good performers (17%; -16 to 43%; p<0.001). To the contrary, the proportion of the poor TMT performance group that made calculation errors under the dual tasking situation was lower than under the single task situation, but higher in the good TMT performance group (poor performers, -1.6%; good performers, +3%; p = 0.035).
Under most challenging conditions, the elderly with poor TMT performance prioritize the cognitive task at the expense of walking velocity. This indicates that poor cognitive flexibility and working memory are directly associated with altered prioritization.

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    • "For the assessment of ST straight walking and turning, participants walked as fast as possible up and down a 20-m distance in an at least 2 m wide hallway for 1 min (Mancini, 2011). ST checking boxes and serial subtracting 7s tasks were performed also as fast as possible while standing (crossing 32 empty boxes on a sheet of paper; subtracting a series of ten consecutive steps of 7) (Bock, 2008;Hobert et al., 2011). For the DT assessment, study participants performed the checking boxes and the subtracting serial 7s tasks also for 1 min, respectively, in parallel with the walking task (Brauer and Morris, 2010). "
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    • "Subjects were recruited from the Tübinger evaluation of risk factors for early detection of neurodegeneration (TREND)-study database (Heinzel et al., 2013, 2014; Hobert et al., 2011). A depressive sample of 49 patients (Out of the TREND study sample, Fig. 1. (A) Illustration of the fNIRS system on a volunteers head. "
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    • "Likewise, the gait parameters that were linked to prefrontal TOI response also differed depending on the task. This finding is not particularly surprising, because the gait modification that is adopted by an individual can be expected to depend on task objectives and also on what facet of performance is prioritized (Al-Yahya et al., 2009; Hobert et al., 2011; Oh-Park et al., 2013). For instance, if a person adopts a cautious gait pattern characterized by greater stance width, then it may be possible to preserve walking speed. "
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