Inhibition of Tumor Growth by Antibody to ADAMTS1 in Mouse Xenografts of Breast Cancer

Division of Breast and Endocrine Surgery, Department of Surgery, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan.
Anticancer research (Impact Factor: 1.83). 11/2011; 31(11):3839-42.
Source: PubMed


A disintegrin and metalloproteinase with thrombospondin motifs-1 (ADAMTS1), a member of the ADAMTS family of proteases, is involved in the shedding of epidermal growth factor (EGF)-like ligands such as amphiregulin, which activate the EGF receptor. Since ADAMTS1 has been implicated in aggressive breast carcinogenesis, we examined potential antitumor effects of antibody to ADAMTS1 in a mouse model of breast cancer.
BALB/c female mice were inoculated with syngenic 4T1 breast cancer cells and treated with anti-ADAMTS1 antibody or control IgG. Tumor volume and weight were evaluated.
Mouse 4T1 cells expressed ADAMTS1 and its substrates amphiregulin and heparin-binding EGF. Treatment with antibody to ADAMTS1 inhibited tumor growth without any adverse effects.
ADAMTS1 could be a promising molecular target for immunotherapy of breast cancer.

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    • "Many studies have highlighted its functional activity during tumorigen - ic transformation ( Bonuccelli et al . , 2009 ; Choi et al . , 2008 ; Gustavsson et al . , 2008 , 2009 ; Hirano et al . , 2011 ; Ifon et al. , 2005 ; Tan et al. , 2013 ; Kohno et al. , 2010 ; Kuno et al. , 2004 ; Lind et al. , 2006 ; Liu et al. , 2006 ; Masui et al . , 2001 ; Ricciardelli et al . , 2011 ; Rocks et al . , 2008a , b ; Tyan et al . , 2012 ; Yegnasubramanian et al . , 2011 ) . ADAMTS1 dysregulation is linked to the most commonly diagnosed cancers ."
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