Variability of total thiol compounds, oxidative and nitrosative stress in uncomplicated pregnant women and nonpregnant women

Department of Biochemistry, Faculty of Pharmacy, Gazi University, 06330 Etiler-Ankara, Turkey.
Archives of Gynecology (Impact Factor: 1.36). 11/2011; 285(5):1319-24. DOI: 10.1007/s00404-011-2150-0
Source: PubMed


The objective of this study was to determine the changes in total plasma thiols (homocysteine, cysteine and cysteinylglycine), lipid peroxidation and nitric oxide concentrations during normal pregnancy.
These variables were measured in 28 uncomplicated pregnant women at first, second and third trimesters and in 19 nonpregnant women.
The mean concentrations of homocysteine, cysteine and cysteinylglycine were significantly lower in all trimesters of pregnancy compared with nonpregnant controls. There was significant elevation in serum lipid peroxidation levels of pregnant women within first and third trimesters compared with nonpregnant women. In spite of increase in mean nitric oxide levels in pregnant women, this increase did not reach statistically significant levels.
This study provides information about the changes in plasma levels of many variables having important role in pregnancy complication during all trimesters in uncomplicated pregnancy compared with nonpregnant women.

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    • ") . It is well documented that deficiency of either folate or vitamin B12 results in hyperhomocysteinaemia ( Takimoto et al . 2011 ) . In our study , maternal homo - cysteine levels significantly increased at T3 . One study indicates that homocysteine levels are higher in the first trimester as compared with the third trimester in pregnant women ( Ozkan et al . 2012 ) . Others indicate that homocysteine concentrations decline slightly in the first trimester and remained approximately con - stant during the second and third trimesters ( Cikot et al . 2001 ) ; still others report that it increases in a stepwise manner during pregnancy ( Holmes et al . 2005 ; Wallace et al . 2008 ) . Recent studies in"
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