Cortical thickness abnormalities associated with depressive symptoms in temporal lobe epilepsy

Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, NY 10016, USA.
Epilepsy & Behavior (Impact Factor: 2.26). 11/2011; 23(1):64-7. DOI: 10.1016/j.yebeh.2011.10.001
Source: PubMed


Depression in patients with temporal lobe epilepsy (TLE) is highly prevalent and carries significant morbidity and mortality. Its neural basis is poorly understood. We used quantitative, surface-based MRI analysis to correlate brain morphometry with severity of depressive symptoms in 38 patients with TLE and 45 controls. Increasing severity of depressive symptoms was associated with orbitofrontal cortex (OFC) thinning in controls, but with OFC thickening in TLE patients. These results demonstrate distinct neuroanatomical substrates for depression with and without TLE, and suggest a unique role for OFC, a limbic region for emotional processing strongly interconnected with medial temporal structures, in TLE-related depressive symptoms.

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Available from: Ruben Kuzniecky, Oct 20, 2014
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