Article

A Review of the Efficacy and Safety of Banaba (Lagerstroemia speciosa L.) and Corosolic Acid

Creighton University, Medical Center, Omaha, NE 68178, USA.
Phytotherapy Research (Impact Factor: 2.66). 11/2011; 26(3):317-24. DOI: 10.1002/ptr.3664
Source: PubMed

ABSTRACT

Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This review summarizes the current literature regarding banaba and its constituents. The hypoglycemic effects of banaba have been attributed to both corosolic acid as well as ellagitannins. Studies have been conducted in various animal models, human subjects and in vitro systems using water soluble banaba leaf extracts, corosolic acid-standardized extracts, and purified corosolic acid and ellagitannins. Pure corosolic acid has been reported to decrease blood sugar levels within 60 min in human subjects. Corosolic acid also exhibits antihyperlipidemic, antioxidant, antiinflammatory, antifungal, antiviral, antineoplastic and osteoblastic activities. The beneficial effects of banaba and corosolic acid with respect to various aspects of glucose and lipid metabolism appear to involve multiple mechanisms, including enhanced cellular uptake of glucose, impaired hydrolysis of sucrose and starches, decreased gluconeogenesis and the regulation of lipid metabolism. These effects may be mediated by PPAR, MAP K, NF-κB and other signal transduction factors. No adverse effects have been observed or reported in animal studies or controlled human clinical trials. Banaba extract, corosolic acid and other constituents may be beneficial in addressing the symptoms associated with metabolic syndrome, as well as offering other health benefits.

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    • "The blood glucose level was reduced significantly after consumption of the tablet containing the herbal composition in comparison to the placebo. The study, however, did not report any weight loss effect of this combination (Stobs et al., 2012). A pilot study (unpublished) was conducted previously on the effects of the present combination on body weight loss. "
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    • "Additional human efficacy and safety studies are warranted, particularly studies assessing the dose- and time-dependent effects of corosolic acid or corosolic acid-standardized Banaba extracts and ellagitannins alone or in combination with other ingredients on blood lipids (triglyceride and cholesterol), insulin and glucose levels as well as weight loss, and weight management. Investigations are needed to clearly define and understand the roles and importance of corosolic acid and related pentacyclic terpene acids relative to the ellagitannins present in Banaba [57]. Finally, additional acute and subchronic animal safety studies are needed. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Banaba (Lagerstroemia speciosa L.) extracts have been used for many years in folk medicine to treat diabetes, with the first published research study being reported in 1940. This paper summarizes the current literature regarding Banaba and its constituents. The hypoglycemic effects of Banaba have been attributed to both corosolic acid as well as ellagitannins. Studies have been conducted in various animal models, human subjects, and in vitro systems using water soluble Banaba leaf extracts, corosolic acid, and ellagitannins. Corosolic acid has been reported to decrease blood sugar levels within 60 min in human subjects. Corosolic acid also exhibits antihyperlipidemic and antioxidant activities. The beneficial effects of Banaba and corosolic acid with respect to various aspects of glucose and lipid metabolism appear to involve multiple mechanisms, including enhanced cellular uptake of glucose, impaired hydrolysis of sucrose and starches, decreased gluconeogenesis, and the regulation of lipid metabolism. These effects may be mediated by PPAR and other signal transduction factors. Banaba extract, corosolic acid, and other constituents may be beneficial in addressing the symptoms associated with metabolic syndrome, as well as offering other health benefits.
    Full-text · Article · Oct 2012 · Evidence-based Complementary and Alternative Medicine
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