Gao L, Mao Q, Cao J, Wang Y, Zhou X, Fan L. Effects of coenzyme Q10 on vascular endothelial function in humans: a meta-analysis of randomized controlled trials
Department of Geriatric Cardiology, General Hospital of Chinese People's Liberation Army, Beijing 100853, China. Atherosclerosis
(Impact Factor: 3.99).
10/2011; 221(2):311-6. DOI: 10.1016/j.atherosclerosis.2011.10.027
The purpose of this study was to quantify the effect of coenzyme Q10 on arterial endothelial function in patients with and without established cardiovascular disease.
Endothelial dysfunction has been implicated in the pathogenesis of atherosclerosis.
The search included MEDLINE, Cochrane Library, Scopus, and EMBASE to identify studies up to 1 July 2011. Eligible studies were randomized controlled trials on the effects of coenzyme Q10 compared with placebo on endothelial function. Two reviewers extracted data on study characteristics, methods, and outcomes. Five eligible trials enrolled a total of 194 patients. Meta-analysis using random-effects model showed treatment with coenzyme Q10 significantly improvement in endothelial function assessed peripherally by flow-mediated dilatation (SMD 1.70, 95% CI: 1.00-2.4, p<0.0001). However, the endothelial function assessed peripherally by nitrate-mediated arterial dilatation was not significantly improved by using fix-effects model (SMD -0.19, 95% CI: -1.75 to 1.38, p = 0.81).
Coenzyme Q10 supplementation is associated with significant improvement in endothelial function. The current study supports a role for CoQ10 supplementation in patients with endothelial dysfunction.
Available from: Mario duran-prado
- "Augmented levels of ROS are common factors in all major vascular diseases . Oral CoQ supplementation has been used recently in clinical trials to improve the endothelial function in type II diabetes and cardiovascular diseases , , , , and a meta-analysis of the randomized controlled trials concluded that CoQ supplementation is associated with significant improvement in endothelial function . It has been proposed a plasma threshold of 2.5 µM, above which positive effects can be observed . "
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Available from: Suleyman Turk
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