Management of sulfur mustard-induced chronic pruritus: A review of clinical trials

Chemical Injuries Research Center, Baquiyatallah University of Medical Sciences, Tehran, Iran.
Cutaneous and Ocular Toxicology (Impact Factor: 1.12). 11/2011; 31(3):220-5. DOI: 10.3109/15569527.2011.631655
Source: PubMed


Skin is among the most heavily damaged organs upon sulfur mustard (SM) exposure. Chronic complications due to SM-induced dermatotoxicity are quite frequent among intoxicated patients. Nevertheless, the exact pathophysiology of SM-induced chronic cutaneous complications has not been well clarified yet. The present review highlights clinically important findings on the management of SM-induced chronic skin complications with a particular focus on pruritus as the most prevalent symptom that has a significant impact on patients' quality of life. Some methodological pitfalls that implicate the validity of the trials have also been identified.

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