ATP-Dependent Chromatin Remodeling Factors and Their Roles in Affecting Nucleosome Fiber Composition

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International Journal of Molecular Sciences (Impact Factor: 2.86). 12/2011; 12(10):6544-65. DOI: 10.3390/ijms12106544
Source: PubMed


ATP-dependent chromatin remodeling factors of the SNF2 family are key components of the cellular machineries that shape and regulate chromatin structure and function. Members of this group of proteins have broad and heterogeneous functions ranging from controlling gene activity, facilitating DNA damage repair, promoting homologous recombination to maintaining genomic stability. Several chromatin remodeling factors are critical components of nucleosome assembly processes, and recent reports have identified specific functions of distinct chromatin remodeling factors in the assembly of variant histones into chromatin. In this review we will discuss the specific roles of ATP-dependent chromatin remodeling factors in determining nucleosome composition and, thus, chromatin fiber properties.

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Available from: Alexandra Lusser, Nov 02, 2015
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    • "There is a precedent for a role of chromatin remodeling ATPases in mitotic epigenetic memory. Metazoan ISWI and CHD1 chromatin remodeling ATPases have been linked to replication-coupled chromatin assembly, and hence epigenetic memory (Piatti et al., 2011; Alabert and Groth, 2012). Moreover, a growing body of evidence has revealed important functions for SWI2/SNF2 subgroup ATPases in nuclear processes other than transcription, including DNA replication (Shaked et al., 2006; Tyagi et al., 2009; Zhao et al., 2009, Cohen et al., 2010; Lee et al., 2010; Euskirchen et al., 2011; Kim et al., 2012). "
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