Myocardial Infarction Associated With Use of the Synthetic Cannabinoid K2
Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75235, USA. PEDIATRICS
(Impact Factor: 5.47).
11/2011; 128(6):e1622-7. DOI: 10.1542/peds.2010-3823
Designer drugs have been problematic over the years. Products such as K2 and Spice, which contain synthetic cannabinoids, are marketed as incense and are widely available on the Internet and at various specialty shops. The effects are reported as cannabis-like after smoking them. In addition, use of these synthetic cannabinoids will not appear on a routine urine toxicology screen. Recently, K2 became a popular alternative to marijuana among youths. Health implications of these designer drugs are not completely understood. Little has been reported about the harmful effects of K2. We report here the first (to our knowledge) cases of myocardial infarction (MI) after smoking K2. Three patients presented separately to the emergency department complaining of chest pain within days after the use of K2. Acute MI was diagnosed in each case on the basis of electrocardiogram changes and elevated troponin levels. Coronary angiography was performed, and the results were normal for the first 2 patients. The incidence of ST-elevation MI is low among teenagers, and association with drug use should be suspected. Public education and awareness need to be heightened about the possible health implications of K2.
Available from: Nadine Schaefer
- "Synthetic cannabinoids emerged on the drug marked a few years ago and are still an issue in forensic toxicology. In the meantime different cases occurred where the consumption of herbal blends containing synthetic cannabinoids was correlated with life-threatening conditions and quite often resulted in admission to the hospital     . There were also some fatalities where the intake of synthetic cannabinoids was related to the cause of death  . "
Available from: Cornelius Hess
- "After the consumption of synthetic cannabinoids both symptoms which are also described after cannabis intoxications (tachycardia, sedation, psychosis, anxiety and panic attacks) and further symptoms like agitation, convulsions, nausea and emesis were detected  . In one case a patient suffered from chest pain after the use of K2 which ended in electrocardiogram changes (ST elevation), elevated troponin levels and myocardial infarction in a 16-year old . Another patient died from sudden cardiac arrest after K2 consumption . "
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ABSTRACT: We present a case study on a man who suffered from diabetic ketoacidosis, probably following consumption of synthetic cannabinoids. In blood from a femoral vein AB-CHMINACA, AB-FUBINACA, AM-2201, 5F-AMB, 5F-APINACA, EAM-2201, JWH-018, JWH-122, MAM-2201, STS135 and THJ 2201 could be detected by LC-MS/MS. Diagnosis of ketoacidosis as cause of death was carried out using biochemical measurements of glucose and lactate concentrations in vitreous humour (sum formula: 463mg/dl) and cerebrospinal fluid (sum formula: 506mg/dl), of acetone (163mg/l in femoral venous blood) and of HbA1c (98mmol/mol). Death due to hyperglycaemia could have been induced by skipping of insulin doses due to his intoxicated state or by the cannabinoids which were described to be able to produce hyperglycaemia themselves.
Available from: Daniele Debruyne
- "In conclusion, there are several evidences       to think that cannabis and SC can lead to serious cardiac disorders but we think that this case report is speculative rather than affirmative (because of the study limitations described above) and therefore, conclusions should be more modulated. "
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