The Candida Genome Database incorporates multiple Candida species: multispecies search and analysis tools with curated gene and protein information for Candida albicans and Candida glabrata

Department of Genetics, Stanford University Medical School, Stanford, CA 94305-5120, USA.
Nucleic Acids Research (Impact Factor: 9.11). 11/2011; 40(Database issue):D667-74. DOI: 10.1093/nar/gkr945
Source: PubMed


The Candida Genome Database (CGD, http://www is an internet-based resource that provides centralized access to genomic sequence data and manually curated functional information about genes and proteins of the fungal pathogen Candida albicans and other Candida species. As the scope of Candida research, and the number of sequenced strains and related species, has grown in recent years, the need for expanded genomic resources has also grown. To answer this need, CGD has expanded beyond storing data solely for C. albicans, now integrating data from multiple species. Herein we describe the incorporation of this multispecies information, which includes curated gene information and the reference sequence for C. glabrata, as well as orthology relationships that interconnect Locus Summary pages, allowing easy navigation between genes of C. albicans and C. glabrata. These orthology relationships are also used to predict GO annotations of their products. We have also added protein information pages that display domains, structural information and physicochemical properties; bibliographic pages highlighting important topic areas in Candida biology; and a laboratory strain lineage page that describes the lineage of commonly used laboratory strains. All of these data are freely available at http://www We welcome feedback from the research community at [email protected]
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    • "Wor4 homologs in fungal species were identified using the Fungal Genomes Search tool at the Saccharomyces Genome Database (Cherry et al. 2012) using the BLASTP tool (except for W. anomalus which used the TBLASTN tool) (Altschul et al. 1990). The protein sequence for the best hit in a given species was then compared to the C. albicans genome using the BLASTP tool at the Candida Genome Database (Inglis et al. 2012). A Wor4 homolog was considered to be present in a given species if both BLAST searches gave a hit with an E-value better than 1e-5 and if Wor4 was the highest scoring hit for the C. albicans genome. "
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