A single institution experience of streptozocin/fluorouracil combination chemotherapy: A case series

Trinity College Dublin, St. James's Hospital, James's Street, Dublin 2, Ireland.
Irish Journal of Medical Science (Impact Factor: 0.83). 11/2011; 181(2):211-4. DOI: 10.1007/s11845-011-0780-7
Source: PubMed


The combination chemotherapy regimen of streptozocin and 5-fluorouracil (FU/STZ) has been used for the treatment of metastatic neuroendocrine tumours.
The aim of this study was to analyse the use of this regimen in a tertiary oncology referral centre over a 10-year period.
We retrospectively analysed nine cases from February 2000 to May 2010. Patient demographics, chemotherapy schedule, toxicities, progression-free and overall survival were tabulated for each patient.
The median progression-free survival was 17 months (range 3-48+ months), and overall survival 31 months (range 12-53+ months) with no toxicity related deaths.
FU/STZ was a well-tolerated regimen that produced significant benefit in the setting of metastatic and progressive disease. Our case series demonstrated comparable progression-free survival and overall survival in relation to randomized controlled studies and previous case series.

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