Quadriparesis and dysarthria due to tetrabenazine therapy in a child with rheumatic chorea

ArticleinIndian Journal of Pharmacology 43(5):601-2 · September 2011with3 Reads
Impact Factor: 0.69 · DOI: 10.4103/0253-7613.84982 · Source: PubMed
  • 29.62 · Lokmanya Tilak Municipal General Hospital and Lokmanya Tilak Municipal Medical College
  • 31.81 · ESI Post Graduate Institute of Medical Sciences & Research and MGM Hospital, Parel, Mumbai

Tetrabenazine (TBZ) is widely used to treat hyperkinetic movement disorders in adults; however, published experience with the drug in children is limited. Common side effects of TBZ include drowsiness, sedation, weakness, Parkinsonism, depression, and acute akathisia, all of which are reversible with decreased doses. We report here a 7-year-old girl with rheumatic chorea who developed acute akinesia of all four limbs and dysarthria due to TBZ therapy. Withdrawal of the drug led to rapid improvement within 18 hours.