Pathologically Confirmed Malignant Syphilis in an HIV-Infected Patient

ArticleinInternal Medicine 50(20):2423-6 · January 2011with7 Reads
Impact Factor: 0.90 · DOI: 10.2169/internalmedicine.50.5605 · Source: PubMed


    We report a case of pathologically confirmed malignant syphilis in an HIV-infected patient. Physical examinations revealed ulceronecrotic skin lesions. Skin biopsies demonstrated syphilis spirochetes on immunohistochemical stain, and syphilis serological titers were positive. Treatment with intravenous penicillin G was begun, and complete resolution of the skin lesions was observed. A rapid plasma reagin titer test performed 3 months after treatment revealed a 4-fold reduction in the titer, indicating successful treatment.