p53 Family: Role of Protein Isoforms in Human Cancer

Department of Surgery and Cancer Biology, Vanderbilt University Medical Center, 1255 Light Hall, 2215 Garland Avenue, Nashville, TN 37232, USA.
Journal of nucleic acids 01/2012; 2012(2090-0201):687359. DOI: 10.1155/2012/687359
Source: PubMed


TP53, TP63, and TP73 genes comprise the p53 family. Each gene produces protein isoforms through multiple mechanisms including extensive alternative mRNA splicing. Accumulating evidence shows that these isoforms play a critical role in the regulation of many biological processes in normal cells. Their abnormal expression contributes to tumorigenesis and has a profound effect on tumor response to curative therapy. This paper is an overview of isoform diversity in the p53 family and its role in cancer.

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Available from: Jinxiong Wei, Jun 30, 2014
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    • "For instance, the human tumor-suppressor TP53 gene produces 12 different isoforms through AS, alternative initiation of translation and promoter usage. Although they are expressed in normal human tissues, the balance between these isoforms is altered in a wide range of cancer types contributing to tumorigenesis and to the response to therapy [25]. Thus, deciphering the circuits that control AS of TP53 transcripts may assist in the development of personalized therapies. "
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    • "P53 plays a vital role in carcinogenesis, and many studies have revealed that it is involved with MDR (22). In addition to regulation of apoptosis, P53 modulates the expression of P-gp. "
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    • "The p53 is a transcription factor which prevents free radical-induced gene mutations by detecting and getting rid of oxidatively damaged DNA [76]. Upon stimulation, p53 also induces a host of other genes which in turn cause cell cycle arrest and apoptosis [76, 77]. The loss of function of p53 family is known to contribute to cancer progression. "
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