Detection of Adeno-Associated Virus Viremia in Hematopoietic Cell Transplant Recipients

Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
The Journal of Infectious Diseases (Impact Factor: 6). 12/2011; 204(11):1746-9. DOI: 10.1093/infdis/jir655
Source: PubMed


Adeno-associated virus (AAV) is widely considered to be nonpathogenic, but the clinical epidemiology of this virus is limited. By use of polymerase chain reaction assays, we investigated the incidence and clinical significance of AAV viremia in a population of consecutive recipients of a hematopoietic cell transplant (HCT). Four (2.8%) of 145 patients developed AAV viremia after HCT. Viremia was low level and transient in all patients. Two patients were admitted to the hospital and died in proximity to AAV viremia (<7 weeks between diagnosis and death); however, AAV was not detected in tissue specimens obtained at autopsy. Thus, AAV does not appear to play a pathogenic role in organ-specific illness, even in a highly immunocompromised population.

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    ABSTRACT: We show that there is a first order sentence ϕ(x; a, b, l) such that for every computable partial order P and ∆ 0 2 -degree u > 0 e , there are ∆ 0 2 -enumeration degrees a ≤ u, b, and l such that P ∼ = {x : ϕ(x; a, b, l)}. Allowing P to be a suitably defined standard model of arithmetic gives a parameterized interpretation of true arithmetic in the ∆ 0 2 -enumeration degrees. Finally we show that there is a first order sentence that correctly identifies a subset of the standard models, which gives a parameterless interpretation of true arithmetic in the ∆ 0 2 -enumeration degrees.
    Full-text · Article · Jun 2010 · Journal of Symbolic Logic