Hemogenic endothelium: origins, regulation, and implications for vascular biology. Semin Cell Dev Biol

Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA.
Seminars in Cell and Developmental Biology (Impact Factor: 6.27). 12/2011; 22(9):1036-47. DOI: 10.1016/j.semcdb.2011.10.003
Source: PubMed


The study of endothelial development has been intertwined with hematopoiesis since the early 20th century when a bi-potential cell (hemangioblast) was noted to produce both endothelial and hematopoietic cells. Since then, ideas regarding the nature of connection between the vascular and hematopoietic systems have ranged from a tenuous association to direct lineage origination. In this review, historical data that spans hematopoietic development is examined within the context of hemogenic endothelium. Hemogenic endothelium, a specialized endothelial population capable of hematopoiesis, is an emerging theory that has recently gained momentum. Evidence across species and decades are reviewed, as are the possible modulators of the phenomenon, which include pathways that specify definitive hematopoiesis (Runx1), arterial identity (Notch1), as well as physiological and developmental factors.

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Available from: Ann C Zovein, Oct 26, 2015
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    • "Regulation of the endothelial and hematopoietic lineage specification has stimulated intense interest (Chen et al., 2009; Eilken et al., 2009; Hirschi, 2012; Lancrin et al., 2009). A number of transcription factors and signaling pathways have been reported to play important roles in the regulation of endothelial and hematopoietic mesodermal progenitors (Zape and Zovein, 2011). GATA transcription factors are characterized as having a conserved dual zinc finger domain. "
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