Body Mass Index and Mortality Rate among Hispanic Adults: A Pooled Analysis of Multiple Epidemiologic Datasets

Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
International journal of obesity (2005) (Impact Factor: 5). 10/2011; 36(8):1121-6. DOI: 10.1038/ijo.2011.194
Source: PubMed


To evaluate the association between body mass index (BMI, kg m⁻²) and mortality rate among Hispanic adults.
Analysis of five data sets (total N=16,798) identified after searching for publicly available, prospective cohort data sets containing relevant information for at least 500 Hispanic respondents (≥18 years at baseline), at least 5 years of mortality follow-up, and measured height and weight. Data sets included the third National Health and Nutrition Examination Survey, the Puerto Rico Heart Health Program (PRHHP), the Hispanic Established Population for Epidemiologic Studies of the Elderly (HEPESE), the San Antonio Heart Study (SAHS) and the Sacramento Area Latino Study on Aging.
Cox proportional hazards regression models, adjusting for sex and smoking, were fit within three attained-age strata (18 to younger than 60 years, 60 to younger than 70 years, and 70 years and older). We found that underweight was associated with elevated mortality rate for all age groups in the PRHHP (hazard ratios [HRs]=1.38-1.60) and the SAHS (HRs=1.88-2.51). Overweight (HRs=0.38 and 0.84) and obesity grade 2-3 (HRs=0.75 and 0.60) associated with reduced mortality rate in the HEPESE dataset for those in the 60 to younger than 70 years, and 70 years and older attained-age strata. Weighted estimates combining the HRs across the data sets revealed a similar pattern.
Among Hispanic adults, there was no clear evidence that overweight and obesity associate with elevated mortality rate.

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    • "Finally, large datasets in broad and diverse populations need to continue to be generated, made publically available, and analyzed so we may better discern the extent to which the BMI–mortality relationship differs between groups and over time [19]. There is also a clear need for randomized studies of obesity-related interventions intended to increase lifespan and an assessment of their actual effects on lifespan or mortality. "
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