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Mantis, N.J., Rol, N. & Corthesy, B. Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol. 4, 603-611

Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.
Mucosal Immunology (Impact Factor: 7.37). 11/2011; 4(6):603-11. DOI: 10.1038/mi.2011.41
Source: PubMed

ABSTRACT

Secretory IgA (SIgA) serves as the first line of defense in protecting the intestinal epithelium from enteric toxins and pathogenic microorganisms. Through a process known as immune exclusion, SIgA promotes the clearance of antigens and pathogenic microorganisms from the intestinal lumen by blocking their access to epithelial receptors, entrapping them in mucus, and facilitating their removal by peristaltic and mucociliary activities. In addition, SIgA functions in mucosal immunity and intestinal homeostasis through mechanisms that have only recently been revealed. In just the past several years, SIgA has been identified as having the capacity to directly quench bacterial virulence factors, influence composition of the intestinal microbiota by Fab-dependent and Fab-independent mechanisms, promote retro-transport of antigens across the intestinal epithelium to dendritic cell subsets in gut-associated lymphoid tissue, and, finally, to downregulate proinflammatory responses normally associated with the uptake of highly pathogenic bacteria and potentially allergenic antigens. This review summarizes the intrinsic biological activities now associated with SIgA and their relationships with immunity and intestinal homeostasis.

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Available from: Blaise Corthésy, Jul 02, 2014
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    • "In this study, we also found that dietary supplementation with L. plantarum B1 significantly increased the ileal mucosal sIgA compared with the control. sIgA serves as the first line of defense in protecting the intestinal epithelium from enteric toxins and pathogenic microorganisms, and maintains mucosal homeostasis in the gut (Mantis et al., 2011). The increase in sIgA helps to enhance intestinal mucosal health, which might lead to increased nutrient absorption , thereby improving the performance of broilers. "
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    • "Multiple cytokines, including interleukin (IL)-4, transforming growth factor (TGF)-b, IL-5, IL-6, and IL-10 are instrumental in intestinal stimulation of SIgA production. A subset of these cytokines, notably TGF-b and IL-10, is also required for maintaining mucosally induced tolerance, thus establishing one of the many links between SIgA production, immunity, and intestinal homeostasis (Mantis et al. 2011). "
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    ABSTRACT: The in vitro and in vivo effects of crude polysaccharide isolated from Korean persimmon vinegar (KPV-0) on the intestinal immunostimulation were examined. KPV-0 was not cytotoxic to intestinal epithelial Caco-2 cells and could be transported through a Caco-2 cell monolayer in an in vitro coculture system. For and in vitro experiment, KPV-0 treatment significantly increased IgA production by Peyer’s patch (PP) cells and triggered an increase in transforming growth factor (TGF)-β1 and interleukin (IL)-6 levels. To investigate the in vivo effects of KPV-0 treatment, KPV-0 was administered to mice orally at different doses for 20 days. Oral administration of KPV-0-induced IgA and cytokines (IL-6, granulocyte macrophage-colony-stimulating factor, and TGF-β) production by PP cells and significantly increased the IgA levels in intestinal fluids and feces. These results suggested that the polysaccharides isolated from persimmon vinegar appear to modulate the intestinal immune system and could be beneficial to human health.
    Full-text · Article · Sep 2015 · Journal of the Korean Society for Applied Biological Chemistry
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    • "It has been postulated that SIgA mediates immune exclusion at least in part by trapping microbes in the mucus layer overlying the epithelium of mucosal surfaces [20] [43]. An in vivo study in mice demonstrated that N-glycan side chains on the SC moiety anchor SIgA to the mucus gel lining the luminal surface of the respiratory tract [43]. "
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