Article

Extraordinary metabolic stability of peptides containing α-aminoxy acids

Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, People's Republic of China.
Amino Acids (Impact Factor: 3.29). 10/2011; 43(1):499-503. DOI: 10.1007/s00726-011-1095-8
Source: PubMed

ABSTRACT

The metabolic stability of peptides containing a mixed sequence of alpha-aminoxy acids and alpha-amino acids is significantly improved compared to peptides composed of only natural alpha-amino acids. The introduction of an alpha-aminoxy acid into peptide chain dramatically improves the stability of the amide bonds immediately before and after it. These peptides containing alpha-aminoxy acids represent excellent structural scaffold for the design of metabolically stable and biologically active peptides.

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