Korkaya H, Liu S, Wicha MSBreast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest 121: 3804-3809

Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA.
The Journal of clinical investigation (Impact Factor: 13.22). 10/2011; 121(10):3804-9. DOI: 10.1172/JCI57099
Source: PubMed


Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.

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Available from: Max S Wicha, May 09, 2014
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    • "Niches have been identified for mammalian stem cells in various epithelial tissues , such as the intestine as well as in neural, epidermal, and hematopoietic systems (Voog and Jones, 2010). Normal niches are comprised of fibroblastic cells, immune cells, endothelial and perivascular cells or their progenitors, extracellular matrix (ECM) components, and networks of cytokines and growth factors (Korkaya et al., 2011). The CSC niche itself is a part of the tumor microenvironment (TME), which is a collective term for the adjacent stroma along with the normal counterparts of the tumorigenic cells (Hanahan and Coussens, 2012). "
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    ABSTRACT: Cancer stem cells (CSCs) are tumor cells that have the principal properties of self-renewal, clonal tumor initiation capacity, and clonal long-term repopulation potential. CSCs reside in niches, which are anatomically distinct regions within the tumor microenvironment. These niches maintain the principle properties of CSCs, preserve their phenotypic plasticity, protect them from the immune system, and facilitate their metastatic potential. In this perspective, we focus on the CSC niche and discuss its contribution to tumor initiation and progression. Since CSCs survive many commonly employed cancer therapies, we examine the prospects of targeting the niche components as preferable therapeutic targets. Copyright © 2015 Elsevier Inc. All rights reserved.
    Full-text · Article · Mar 2015 · Cell Stem Cell
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    • "The situation radically changed in recent years where both Bioinformatics and Biotechnology fostered the discovery of unexpected facts that are changing the picture we had of biological systems. Just to name a few the modification of the molecular biology central dogma [4], the richness of post transcription and post-translational modifications [5], the discovery of unexpected correlation structures among cells [6], the role of microenvironment in cancer [7] were all made possible by a creative use of Bioinformatics and Biotechnology. "

    Full-text · Article · Feb 2015
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    • "Paraneoplastic exanthems might rather be attributed to a complicated interaction of cytokines (interleukin 1-2-8) and cellular adhesion molecules (VCAM-1, ICAM-1, E-selectin, and P-selectin), causing binding, transmigration, and infiltration of lymphocytes and mononuclear cells, which finally results in significant epidermal turnover rate [2, 14, 15]. Breast cancer is also a well-known source of such cytokine and cellular adhesion molecules overproduction [16, 17]. "
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    ABSTRACT: The skin may exhibit the first clinical evidence of a systemic disease and may provide the first clues to a diagnosis in malignancies. Erythroderma is defined as generalized redness and scaling and it is a clinical manifestation of a variety of underlying diseases including, rarely, solid tumors. Breast cancer is associated with a variety of skin paraneoplastic manifestations like acanthosis nigricans, erythromelalgia, thrombotic thrombocytopenic purpura, acrokeratosis paraneoplastica, dermatomyositis, systemic sclerosis, and scleroderma. However, in the literature, the correlation of erythroderma with breast cancer is quite infrequent. Here, we describe a case of a 76-year-old woman who presented with a paraneoplastic manifestation of erythroderma due to breast cancer.
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