Unpredictability and Uncertainty in Anxiety: A New Direction for Emotional Timing Research

Center for Cognitive Neuroscience, Duke University Durham, NC, USA.
Frontiers in Integrative Neuroscience 09/2011; 5:55. DOI: 10.3389/fnint.2011.00055
Source: PubMed
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Available from: Kevin S. LaBar, Jun 11, 2014
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    • "Moreover, the prefrontal cortex has been strongly implicated in duration processing (Brunia et al., 2000; Lewis and Miall, 2003; Smith et al., 2003), possibly through working memory related functional integration of time related information or direction of attentional resources (Meck and Macdonald, 2007). Prior research suggests that some anxiety disorders such as PTSD, but not all, are operated through a shared neural pathway underlying the experience of temporal unpredictability during anticipation (Lake and Labar, 2011). Specifically, the anterior insula and the striatum appear to be activated during the expectation and evaluation of upcoming events in healthy controls (Lovero et al., 2009; Wittmann et al., 2010a). "
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