Crystal Structure of a Monomeric Retroviral Protease Solved by Protein Folding Game Players

Department of Biochemistry, University of Washington, Seattle, Washington, USA.
Nature Structural & Molecular Biology (Impact Factor: 13.31). 09/2011; 18(10):1175-7. DOI: 10.1038/nsmb.2119
Source: PubMed


Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs.

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Available from: Helena Zábranská, Sep 09, 2014
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    • "The highest scoring solutions are analysed by researchers and validated if applicable in real problems or not. Users in Foldit has already helped to decipher the crystal structure of the Mason-Pfizer monkey virus retroviral protease [19]. "

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