HIV Infection-Related Premature Immunosenescence: High Rates of Immune Exhaustion After Short Time of Infection

Laboratory of Immunovirology, Biomedicine Institute of Seville, Service of Infectious Diseases, Virgen del Rocío University Hospital, Seville, Spain.
Current HIV research (Impact Factor: 1.76). 09/2011; 9(5):289-94. DOI: 10.2174/157016211797636008
Source: PubMed


Premature immunosenescence has been reported in different HIV scenarios. However, how premature is the HIV-related immunosenescent phenotype is still unknown. Thus, the aim of this study was to analyze the immunosenescent status of young viraemic naive HIV-infected individuals, with less than four years from infection. To this end, replicative senescence, activation and proliferation T-cell levels were analyzed in chronically HIV-infected young individuals and both, elderly and young healthy controls. We show that young HIV-infected viraemic patients, with less than four years from infection, have early immune exhaustion leading to a premature immunosenescence comparable to healthy people 40 years elder. In addition, memory T-cell subsets showed greater alterations than elder healthy controls and, in patients with high viral loads, CD57 expression at the memory T-cell subsets was correlated with lower viral increases but higher CD4 T-cell lost during follow up.

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Available from: Sara Ferrando-Martinez
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    • "Most research in this relatively new field focuses on how HIV-1 infection depletes CD4+ cell counts and exhausts the patient’s immune system (Appay and Sauce, 2008; Desai and Landay, 2010). In this way, HIV-infection itself if left untreated has been shown to convert the immune system of a young individual into one similar to someone 40 years older (Ferrando-Martínez et al., 2011). This theory of an accelerated aging process of the immune system is called immunosenescence and is characterized by continuous immune provocation and systemic low-grade inflammation, which predisposes patients to co-morbidities and natural aging symptoms more frequently seen in the elderly (Dock and Effros, 2011; Deeks et al., 2012). "
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