Integrating clinical research with the Healthcare Enterprise: From the RE-USE project to the EHR4CR platform

INSERM, UMR_S 872 eq20, 15 rue de l'école de médecine, 75006 Paris, France.
Journal of Biomedical Informatics (Impact Factor: 2.19). 08/2011; 44 Suppl 1:S94-102. DOI: 10.1016/j.jbi.2011.07.007
Source: PubMed


There are different approaches for repurposing clinical data collected in the Electronic Healthcare Record (EHR) for use in clinical research. Semantic integration of “siloed” applications across domain boundaries is the raison d’être of the standards-based profiles developed by the Integrating the Healthcare Enterprise (IHE) initiative – an initiative by healthcare professionals and industry promoting the coordinated use of established standards such as DICOM and HL7 to address specific clinical needs in support of optimal patient care. In particular, the combination of two IHE profiles – the integration profile “Retrieve Form for Data Capture” (RFD), and the IHE content profile “Clinical Research Document” (CRD) – offers a straightforward approach to repurposing EHR data by enabling the pre-population of the case report forms (eCRF) used for clinical research data capture by Clinical Data Management Systems (CDMS) with previously collected EHR data.

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Available from: Pierre-Yves Lastic, Mar 12, 2014
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    • "EMR adoption by primary care physicians in Canada has accelerated in the past several years [1]. This has provided an excellent opportunity to repurpose existing clinical data to pre-populate structured forms [2] [3] and to collect structured data at the point of care to facilitate clinical research. One of the advantages of standardized data is to collect patient-centred data for research leading to improved patient care. "
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    • "Former single source projects such as [16] just used locally developed standards to connect their system instead of standardized terminology, whereas newer projects such as [17] [18] use ontologies together with a controlled vocabulary. In comparison, our approach focuses on the facilitation of the mapping and on the implementation of an ontological representation of the semantic annotation for use by client applications. "
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    • "BRIDG [24] (Biomedical Research Integrated Domain Group) model which, on one side, contains representations of clinical research data with underlying mappings to the HL7 RIM and, on the other side, covers a superset of the scope defined by CDASH. Currently, several projects around the world are currently using these standards such as REUSE [25], EHR4CR [18,26], TRANSFORM [19,20] or CaBIG [27]. "
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