Fatty Liver, Abdominal Visceral Fat, and Cardiometabolic Risk Factors The Jackson Heart Study

Jackson Heart Study, University of Mississippi Medical Center, Jackson State University, Jackson, MS 39213-4505, USA.
Arteriosclerosis Thrombosis and Vascular Biology (Impact Factor: 6). 09/2011; 31(11):2715-22. DOI: 10.1161/ATVBAHA.111.234062
Source: PubMed


The goal of this study was to examine whether fatty liver and abdominal visceral adipose tissue (VAT) are jointly associated with cardiometabolic abnormalities.
Black participants were from the Jackson Heart Study (n=2882, 65% women) who underwent computed tomography. Fatty liver was measured by liver attenuation in Hounsfield units (LA), and VAT was quantified volumetrically. Cross-sectional associations between LA, VAT, and cardiometabolic risk factors were assessed using linear and logistic regression, and their joint associations were further examined in 4 subgroups: high-LA/low-VAT (n=1704), low-LA/low-VAT (n=422), high-LA/high-VAT (n=436), and low-LA/high-VAT (n=320). Both LA and VAT were associated with most cardiometabolic traits (all P<0.0001), which persisted after additional adjustment for each other (LA, P<0.01-0.0001; VAT, P<0.0001). In bootstrap analyses, the regression coefficient of VAT was significantly greater than LA for triglycerides, high-density lipoprotein cholesterol, impaired glucose, and metabolic syndrome (P=0.009-0.0001). The interaction between LA and VAT was significant for high-density lipoprotein cholesterol (P=0.002), impaired glucose (P=0.003), and metabolic syndrome (P=0.04). Among 4 subgroups, participants with higher VAT and lower LA had higher prevalence of cardiometabolic traits than those with each condition alone.
Both fatty liver and VAT are independent correlates of cardiometabolic risk, but the associations are stronger for VAT than for fatty liver.

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Available from: Aurelian Bidulescu
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    • "Recent studies have shown independent effects of global visceral adipose tissue on cardiometabolic risks[9,10,30], and other authors have shown that increased regional or peri-coronary EAT predicts both cardiovascular disease and metabolic syndrome161718. In our study, clusters of cardiometabolic risk factors and various measurements of adipose tissue were identified by factor analysis. "
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    ABSTRACT: Background: Previous studies have shown that excessive abdominal visceral adipose tissue (AVAT) and epicardial adipose tissue (EAT) are risk factors of cardiometabolic disease; we hypothesized there is differential contribution of abdominal and cardiac fat deposits to the cardiometabolic profiles. Methods: Two hundred eight consecutive subjects with clinical suspicion of coronary artery disease (CAD) who underwent cardiac and abdominal CT for Agatston score and abdominal visceral fat measurement were retrospectively analyzed. Regional thickness of EAT (EATth), total volume of EAT, total volume of paracardial adipose tissue (PAT) and total volume of AVAT from L2 to L5 level were measured. The relationships between abdominal and cardiac adipose tissue measurements, the number of components of metabolic syndrome, and the severity of Agatston score on a four ranking scale (0, 1-10,11-100, 101-400, >400) were investigated. Results: The amounts of AVAT, EAT, PAT and EATth-LAVG showed a significant linear trend with increasing number (0-5) of components in metabolic syndrome (AVAT, EAT and PAT P for trend <0.0001; EATth-LVAG P for trend <0.001). EATth at left atrioventricular groove (EATth-LAVG) showed significant linear trend with the severity of Agatston score on a four ranking scale (P for trend <0.0001). In multivariate binary regression analysis, total volume of AVAT was the sole adiposity predictor for metabolic syndrome independent to age, gender, and waist circumference (odds ratio of 1.20, 95 % CI 1.08-1.32, p < 0.001) while total volume of EAT, PAT, and EATth-LAVG were not. In contrary, EATth-LAVG was the sole adiposity predictor for Agatston score >400 (odds ratio of 1.11, 95 % CI 1.034-1.184, p = 0.004). Conclusions: Excessive total volume of AVAT appears to be preferentially associated with metabolic syndrome; while EAT, esp. EATth-LAVG is preferentially associated with coronary artery disease. This differential effect of the two adiposities deserves a large-scale cohort study for further investigation.
    Full-text · Article · Dec 2016 · BMC Cardiovascular Disorders
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    • "But despite these strong correlations, gender and race influences these interpretations [25,26]. Excess adipose tissue in the visceral compartment has been associated with increased CVD risk in large prospective studies: the Framingham and the Jackson Heart studies [27,28]. In the present study with the overall body weight gain we were able to demonstrate a significant increase in body fat [+2%] and visceral adipose tissue volume [+0.2(0.03) "
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    Full-text · Article · Jan 2013 · Cardiovascular Diabetology
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    Full-text · Article · Jan 2012 · Obesity
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