Proton magnetic resonance spectroscopy and thought disorder in childhood schizophrenia

Division of Child and Adolescent Psychiatry, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1759, United States.
Schizophrenia Research (Impact Factor: 3.92). 08/2011; 133(1-3):82-90. DOI: 10.1016/j.schres.2011.07.011
Source: PubMed


Although magnetic resonance spectroscopy has identified metabolic abnormalities in adult and childhood schizophrenia, no prior studies have investigated the relationship between neurometabolites and thought disorder. This study examined this association in language-related brain regions using proton magnetic resonance spectroscopic imaging ((1)H MRSI).
MRSI was acquired bilaterally from 28 youth with childhood-onset schizophrenia and 34 healthy control subjects in inferior frontal, middle frontal, and superior temporal gyri at 1.5T and short echo time (TR/TE = 1500/30 ms). CSF-corrected "total NAA" (tNAA; N-acetyl-aspartate + N-acetyl-aspartyl-glutamate), glutamate + glutamine (Glx), creatine + phosphocreatine (Cr + PCr), choline compounds (Cho), and myo-inositol (mI) were assayed in manually drawn regions-of-interest partitioned into gray matter, white matter, and CSF and then coregistered with MRSI. Speech samples of all subjects were coded for thought disorder.
In the schizophrenia group, the severity of formal thought disorder correlated significantly with tNAA in the left inferior frontal and superior temporal gyri and with Cr + PCr in left superior temporal gyrus.
Neurometabolite concentrations in language-related brain regions are associated with thought disorder in childhood-onset schizophrenia.

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    • "Frontal, anterior cingulate and hippocampal regions are the most frequently studied brain regions and the findings were consistent across these brain regions. Only one study has investigated brain metabolites within the superior temporal gyrus (Seese et al., 2011) and reported a correlation between N-acetyl aspartate (NAA) concentrations and thought disorder in children with schizophrenia. However, to our knowledge, no single 1 H MRS study has investigated the superior temporal region and compared the findings in adult patients with schizophrenia and patients with bipolar disorder. "
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