Pharmacological effects of Radix Angelica Sinensis (Danggui) on cerebral infarction

Department of Chinese Medicine, China Medical University Hospital, Taichung 40402, Taiwan. .
Chinese Medicine (Impact Factor: 1.49). 08/2011; 6(1):32. DOI: 10.1186/1749-8546-6-32
Source: PubMed


Radix Angelica Sinensis, the dried root of Angelica sinensis (Danggui), is a herb used in Chinese medicine to enrich blood, promote blood circulation and modulate the immune system. It is also used to treat chronic constipation of the elderly and debilitated as well as menstrual disorders. Research has demonstrated that Danggui and its active ingredients, as anti-arthrosclerotic, anti-hypertensive, antioxidant anti-inflammatory agents which would limit platelet aggregation, are effective in reducing the size of cerebral infarction and improving neurological deficit scores.

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    • "Radix Angelicae Sinensis (Danggui), the dried root of Angelica Sinensis, is an herb often used in Chinese food and Traditional Chinese medicine (TCM). Based on early Chinese medical literature, Danggui can promote blood flow and has been used to treat disorders with blood deficiency (for review see [14]). It is often used in the treatment of gynecological conditions that possess a blood deficiency pattern, such as dysmenorrhea and an irregular menstrual cycle. "
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    ABSTRACT: Danggui (Radix Angelicae Sinensis) is an herb often used in Traditional Chinese medicine. It is used to promote blood flow and has been used in the treatment of myocardial ischemia-reperfusion injury in animal models. Angiotensin II (Ang II) has been shown to play important roles in mediating cardiovascular diseases, and may cause cardiac hypertrophy and apoptosis. This study aimed to investigate whether Danggui has protective effects on Ang II-induced apoptosis in H9c2 cardiomyoblast cells and study the mechanisms involved. We evaluated the effect of Danggui on Ang II-induced apoptosis in an in vitro model. H9c2 cardiomyoblast cells were cultured in serum-free medium for 4 hr, then treated with Danggui (50, 100 μg/ml) 1 hr pre- or post-Ang II treatment. After a further 23 hr of culture, cells were harvested for analyses with assays for apoptosis markers and cell signaling pathways. Our results showed that Ang II induced upregulation of pro-apoptotic Bad, instability of the mitochondria membrane potential, cytochrome c release, caspase-9 and caspase-3 activation and cardiomyocyte apoptosis. Pre- or post-treatment with Danggui reversed all of the above Ang II-induced apoptotic effects in H9c2 cells. Furthermore, the JNK (SP600125) inhibitor completely blocked Danggui inhibition of caspase-3 activation in Ang II-treated H9c2 cells. Our results showed that Danggui either pre-treatment or post-treatment highly attenuated the Ang II-induced apoptosis in cardiomyoblast cells. The findings demonstrated that the anti-apoptosis effect of Danggui is mediated by JNK and PI3k inhibitors.
    Full-text · Article · Sep 2014 · BMC Complementary and Alternative Medicine
    • "Meanwhile, A. sinensis Radix has been used as a common health food supplement for women's care for 1000's of years in China.[23] Pharmacological studies and clinical practices have demonstrated that A. sinensis Radix possesses various bioactivities, including antibacterial, anti-amnestic, and antihypertensive effects,[45] inhibitory effect on acetylcholinesterase,[6] reduced cardiac contraction,[7] activation of protein kinase C,[8] and antitumor activity.[9] Regarding the chemical constituents of A. sinensis Radix, more than 70 compounds, including essential oils, phthalide dimers, organic acids and their esters, vitamins and amino acids, have been identified so far, and various biological activities of the compounds have been reported.[10] "
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    ABSTRACT: Background: Sulfur-fumigation of Angelicae sinensis Radix causes changes in the structure and composition of volatile components. These changes alter the curative effect and the quality of A. sinensis Radix. Materials and methods: In this study, comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC × GC-TOFMS) was employed to investigate the influence of sulfur-fumigation on the volatile components, and to characterize and quantify the chemical composition of the volatile oil of A. sinensis Radix. Results: The present study has shown that sulfur-fumigated A. sinensis Radix samples had significant loss of the main active compounds and a more destructive fingerprint profile compared to non-fumigated samples. Conclusion: From this study, it can be concluded that the combination of GC × GC and TOFMS has potential as a quality monitoring tool in herbal medicine and food processing industries.
    No preview · Article · Jul 2014 · Pharmacognosy Magazine
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    ABSTRACT: The present study was performed to investigate the effects of Jin-Ying-Tang (JYT), a Chinese herbal formula containing Lonicera japonica, Herba taraxaci, Fructus trichosanthis, Fructus forsythia, Radix et rhizoma rhei, Astragalus membranaceus, Angelica sinensis, on rabbit mastitis induced by Staphylococcus aureus. Suckling rabbits were challenged with 1.5 × 10(7) colony forming unit (CFU) of S. aureus at the base of the third pair teats, and they were treated and pretreated with JYT to detect the formula effects. The results showed that JYT could reduce the occurrence of Staphylococcal mastitis in rabbit model. To further investigate the action mechanism of JYT, we examined the leukocyte counts and inflammatory mediator levels such as TNF-α and IL-6 in blood and infected tissue. From histological study and blood analysis, we found that JYT could suppress leukocyte infiltration in infected mammary gland tissue and significantly inhibit the total leukocyte counts and lymphocytes (LYM), monocytes (MON) and granulocytes (GRA) fractions of leukocyte counts in blood. Enzyme-linked immunosorbent assay (ELISA) results showed JYT significantly decreased the TNF-α and IL-6 concentrations in serum and mammary gland. The analysis of these data suggested that JYT effectively inhibited inflammatory responses to reduce the occurrence of mastitis in rabbit model.
    No preview · Article · Feb 2012 · Immunopharmacology and Immunotoxicology
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