Efficacy of Atypical Antipsychotic Medication in the Management of Behaviour Problems in Children with Intellectual Disabilities and Borderline Intelligence: A Systematic Review

University of Birmingham, School of Psychology, Birmingham, UK.
Research in developmental disabilities (Impact Factor: 4.41). 08/2011; 32(6):2121-33. DOI: 10.1016/j.ridd.2011.07.031
Source: PubMed


The use of medications to manage problem behaviours is widespread. However, robust evidence to support their use seems to be lacking. The aim was to review research evidence into the efficacy of atypical antipsychotic medication in managing problem behaviour in children with intellectual disabilities and borderline intelligence. A systematic review was conducted for placebo-controlled randomised double-blind trials. The included studies (N = 6) showed that risperidone was significantly more effective than placebo in managing problem behaviours. However, most studies highlighted adverse events primarily somnolence and weight gain. There is now some evidence in favour of the use of risperidone. However, because of possible adverse events, these medications have to be used with caution.

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Available from: Gemma Unwin, Oct 15, 2015
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    • "Another problem with lithium prescribing is that in some people with severe ID it may not be possible to carry out recommended blood tests. A prospective 12 months follow-up study found little evidence of use of lithium in ID by UK psychiatrists (Unwin et al., 2011). There is not as yet much evidence for the effectiveness of other mood stabilizers such as sodium valproate, carbamazepine, and lamotrigine, which may provide a better alternative to lithium. "
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