Value of Diffusion-Weighted Imaging in Grading Tumours Localized in the Fourth Ventricle Region by Visual and Quantitative Assessments

Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
The Journal of international medical research (Impact Factor: 1.44). 06/2011; 39(3):912-9. DOI: 10.1177/147323001103900325
Source: PubMed


This study investigated visual and quantitative assessment of diffusion-weighted imaging (DWI) for grading tumours localized in the fourth ventricle region. Patients were diagnosed histopathologically and classified into two groups: those with high-grade (World Health Organization [WHO] grades III and IV) and those with low-grade tumours (benign, WHO grades I and II). DWI signal intensity was described using a five-point scale. Minimum apparent diffusion coefficient (ADC) values were obtained from areas with the lowest signal. The mean signal intensity was significantly higher in high-grade than in low-grade tumours. The mean minimum ADC value was significantly lower in high-grade than low-grade tumours. Marked hyperintensity had sensitivity, specificity, positive predictive value and negative predictive value of 89.7%, 100%, 100% and 94.2%, respectively, when used as a diagnostic tool for high-grade tumours compared with 96.6%, 97.9%, 96.6% and 97.9%, respectively, when using a minimum ADC of 0.9 × 10(-3) mm(2)/s as a diagnostic marker. It was concluded that DWI is helpful in predicting the grades of tumours in the fourth ventricle region.

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Available from: Bing Cang Huang, Jan 11, 2014
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