Finding the missing code of RNA recognition by PUF proteins

Department of Chemistry, University of Washington, Seattle, WA 98195, USA.
Chemistry & biology (Impact Factor: 6.65). 07/2011; 18(7):821-3. DOI: 10.1016/j.chembiol.2011.07.001
Source: PubMed


Pumilio and FBF homology (PUF) proteins represent highly promising candidates for engineering sequence-specific RNA recognition, but were only known to recognize G, A, and U, significantly limiting applications. Two groups (Filipovska et al., 2011; Dong et al., 2011) have now reported the discovery of the cytosine-recognition code for PUF proteins.

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