Multimodality Molecular Imaging of Apoptosis in Oncology

Department of Radiology, Division of Pediatric Radiology, Lucile Salter Packard Children's Hospital, 725 Welch Rd, Palo Alto, CA 94304, USA.
American Journal of Roentgenology (Impact Factor: 2.73). 08/2011; 197(2):308-17. DOI: 10.2214/AJR.11.6953
Source: PubMed


OBJECTIVE: The purposes of this review are to describe the signaling pathways of and the cellular changes that occur with apoptosis and other forms of cell death, summarize tracers and modalities used for imaging of apoptosis, delineate the relation between apoptosis and inhibition of protein translation, and describe spectroscopic technologies that entail high-frequency ultrasound and infrared and midinfrared light in characterizing the intracellular events of apoptosis. CONCLUSION: Apoptosis is a highly orchestrated set of biochemical and morphologic cellular events. These events present many potential targets for the imaging of apoptosis in vivo. Imaging of apoptosis can facilitate early assessment of anticancer treatment before tumor shrinkage, which may increase the effectiveness of delivery of chemotherapy and radiation therapy and speed drug development.

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Available from: Francis Blankenberg, Feb 24, 2015
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    • "To assess the apoptotic effect of MWCNTs-PEG following Laser treatment, we examined the translocation of phosphatidyl serine (PS) groups from the inner to the exterior surface of the membrane as marker of early apoptosis state induction 19. Using the high affinity of annexin to PS groups we were able to detect the apoptosis rate in all samples. "
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    • "Moreover, apoptosis directly represents tumor cell death, while 18F-FDG uptake represents tumor metabolism and thus indirectly represents tumor cell death. Apoptotic cells put signatures or biomarkers on their surface, such as phosphatidylserine and histone H1, that are little or absent on the surface of healthy cells [15]–[17]. Apoptosis imaging probes such as annexin V and dipicoyl zinc amide that bind to phosphatidylserine have been exploited for monitoring tumor cell apoptosis in vivo [15]–[17]. "
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