... Plasma samples of baseline and follow-up time points were processed according to the manufacturer's instructions (PreOmics iST kit, no.iST 96x). Briefly, 4 µL of individual samples were solubilized in 50 μL of "Lyse" buffer (containing Tris-HCl, sodium deoxycholate (SDC), 0.1% sodium dodecyl sulfate (SDS), tris (Yung et al., 2005;Wu et al., 2005;Hutchinson et al., 1999;Horan et al., 2006;Ventura et al., 2011;Robinson et al., 2004;Tohen et al., 2000;Bora and Pantelis, 2013;Carrión et al., 2013;Fusar-Poli et al., 2012;Giuliano et al., 2012;Lin et al., 2011;Meyer et al., 2014;Salokangas et al., 2013;Salokangas et al., 2014;Burton et al., 2019;Cannon et al., 2008;Buchy et al., 2014;Fusar-Poli et al., 2010;Dragt et al., 2011;Tarbox et al., 2013;Ziermans et al., 2014;Riecher-Rössler et al., 2009;Pukrop et al., 2007;Koutsouleris et al., 2012;Hoffman et al., 2007;Nieman et al., 2014;Lencz et al., 2006;Cornblatt et al., 2015;Corcoran et al., 2015;Thompson et al., 2011;Zimmermann et al., 2010;Albert et al., 2017;Miglietta et al., 2020;Tsuang et al., 2013;Riecher-Rössler and Studerus, 2017;Koutsouleris et al., 2018;Koutsouleris et al., 2015;van Tricht et al., 2014;Ramyead et al., 2016;Van Tricht et al., 2010;Muller et al., 2015;Müller, 2018;Hsu et al., 2020;Marrone and Coccurello, 2019;Healy-Stoffel and Levant, 2018;English et al., 2018;Focking et al., 2016;Focking et al., 2019;Heurich et al., 2021;Cannon et al., 2014;Berger et al., 2017;Smesny et al., 2014;Amminger et al., 2010;Susai et al., 2021;Perkins et al., 2015;Chan et al., 2015;Mongan, in press;Niendam et al., 2007;Bryson and Bell, 2003;Bowie et al., 2008;McFarlane et al., 2015;McFarlane et al., 2015;Allen et al., 2015;Markulev et al., 2017;Sekar et al., 2017;Sekar et al., 2016;McGorry et al., 2015;Overall and Gorham, 1962;Andreasen, 1989;Young et al., 1978;Montgomery and Asberg, 1979;Goldman et al., 1992;Auther and Global, 2006;Niendam et al., 2006;Alqarni et al., 2018;McLaverty et al., 2020;Kim et al., 2016;Bache et al., 2018;Beck et al., 2015;Meier et al., 2018;Cox and Mann, 2008;Malipatil et al., 2019;Morrison et al., 2012;Dwyer and Koutsouleris, 2022;n/a(n/ a).; Dwyer et al., 2018;Shatte et al., 2019;Koutsouleris et al., 2016;Ohara, 2007;Das, 2006;Kiecolt-Glaser et al., 2011;Kiecolt-Glaser et al., 2012;Pawelczyk et al., 2015;Cadenhead et al., 2018;Amminger et al., 2013;Berger et al., 2018;Cornblatt et al., 2012;Pouget et al., 2014;Pouget, 2018; phosphine (TCEP), and 2-chloroacetamide and heated to 95 • C for 10 min. 50 μL of the resulting denatured, reduced, and alkylated solution was transferred to the reaction tube. ...