Reduction in Acute Filariasis Morbidity during a Mass Drug Administration Trial to Eliminate Lymphatic Filariasis in Papua New Guinea

Case Western Reserve University, Cleveland, Ohio, USA.
PLoS Neglected Tropical Diseases (Impact Factor: 4.45). 07/2011; 5(7):e1241. DOI: 10.1371/journal.pntd.0001241
Source: PubMed


Acute painful swelling of the extremities and scrotum are debilitating clinical manifestations of Wuchereria bancrofti infection. The ongoing global program to eliminate filariasis using mass drug administration is expected to decrease this and other forms of filarial morbidity in the future by preventing establishment of new infections as a consequence of eliminating transmission by the mosquito vector. We examined whether mass treatment with anti-filarial drugs has a more immediate health benefit by monitoring acute filariasis morbidity in Papua New Guinean communities that participated in a 5-year mass drug administration trial.


Available from: Daniel Tisch
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    • "It is likely that a reduced man-vector contact due to improved mosquito proofing of houses and use of bed nets, in combination with the many MDA applications, are the main reasons for this promising finding. Bm14 prevalences are usually found to be higher than CFA prevalences, even after application of MDAs (Weil et al., 2008; Joseph et al., 2011b), but a similar lower Bm14 than CFA prevalence was also observed after four high compliance MDAs in Papua New Guinea (Tisch et al., 2011). By using two wealth indicators (family possession of fridge and/or TV), the questionnaire survey among the pupils showed that the average economic capability of their families decreased when moving from the centre to the periphery of the city. "
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