Impact of Obesity on Stroke Outcome
After Intravenous Thrombolysis
Authors: Hakan Sarikaya, MD1; Firat Elmas1; Marcel Arnold, MD2; Dimitrios Georgiadis, MD1;
Ralf W. Baumgartner, MD1
1Department of Neurology, University Hospital of Zurich, Switzerland
2Department of Neurology, University Hospital of Bern, Switzerland
Search terms: Ischemic stroke, Obesity, Thrombolysis
Character count for the title: 49
Word count for the abstract: 211
Word count for the manuscript: 1093
Number of references: 15
Number of Tables: 1
Number of Figures: 1
The authors report no disclosures
Address for correspondence:
Hakan Sarikaya, MD
University Hospital of Zurich
8091 Zurich, Switzerland
Tel. +41 44 255 11 11
Fax +41 44 255 88 64
Background and Purpose
Obesity is an established risk factor for stroke and has reached epidemic proportions.
However, its impact on intravenous thrombolysis (IVT) applied for acute ischemic
stroke is not well known. We aimed to compare the clinical outcome and safety after
IVT in obese (body mass index (BMI) ≥30 kg/m2) and non-obese (BMI <30 kg/m2)
patients with ischemic stroke.
Data of 304 consecutive stroke patients (251 non-obese and 53 obese) treated with
IVT were studied. We assessed the rate of favorable outcome (modified Rankin Scale
score 0 or 1), mortality and symptomatic intracranial hemorrhage (sICH) in the two
Obese patients presented more often with diabetes mellitus (30.2% vs. 12.4%, p<0.01)
and arterial hypertension (77.4% vs. 61.4%, p=0.03) as compared with their non-obese
counterparts. At three months, the rate of favorable outcome was lower in obese
compared to non-obese patients (50.9% vs. 68.1%, p=0.02). More obese than non-
obese patients died (13.2% vs. 4.0%, p=0.01), while the rate of sICH was similar in the
two groups (1.9% vs. 1.6%, p=1.0). After multivariable adjustment, obesity still
remained an independent predictor of unfavorable outcome (p=0.04) and mortality
Our data indicate that obesity is an independent predictor of unfavorable clinical
outcome and mortality in acute ischemic stroke treated with IVT.
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