Relation of Increased Prebeta-1 High-Density Lipoprotein Levels to Risk of Coronary Heart Disease

Applied Quantitative Genotherapeutics, Pfizer Pharmaceuticals, Cambridge, Massachusetts, USA.
The American journal of cardiology (Impact Factor: 3.28). 08/2011; 108(3):360-6. DOI: 10.1016/j.amjcard.2011.03.054
Source: PubMed


Preβ-1 high-density lipoprotein (HDL) plays a key role in reverse cholesterol transport by promoting cholesterol efflux. Our aims were (1) to test previous associations between preβ-1 HDL and coronary heart disease (CHD) and (2) to investigate whether preβ-1 HDL levels also are associated with risk of myocardial infarction (MI). Plasma preβ-1 HDL was measured by an ultrafiltration-isotope dilution technique in 1,255 subjects recruited from the University of California-San Francisco Lipid and Cardiovascular Clinics and collaborating cardiologists. Preβ-1 HDL was significantly and positively associated with CHD and MI even after adjustment for established risk factors. Inclusion of preβ-1 HDL in a multivariable model for CHD led to a modest improvement in reclassification of subjects (net reclassification index 0.15, p = 0.01; integrated discrimination improvement 0.003, p = 0.2). In contrast, incorporation of preβ-1 HDL into a risk model of MI alone significantly improved reclassification of subjects (net reclassification index 0.21, p = 0.008; integrated discrimination improvement 0.01, p = 0.02), suggesting that preβ-1 HDL has more discriminatory power for MI than for CHD in our study population. In conclusion, these results confirm previous associations between preβ-1 HDL and CHD in a large well-characterized clinical cohort. Also, this is the first study in which preβ-1 HDL was identified as a novel and independent predictor of MI above and beyond traditional CHD risk factors.

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    • "CHD patients often have increased small discoidal HDL particles and decreased large α-1 and α-2 HDL particles [10]. The preβ1-HDL was identified as a novel and independent predictor of myocardial infarction (MI) above and beyond traditional CHD risk factors [11]. Other study showed that small HDL particle size was associated with an increased CHD risk, but this association was largely explained by traditional risk factors [12]. "
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