Predictors of Treatment Acceptance and of Participation in a Randomized Controlled Trial Among Women with Anorexia Nervosa

Regional Centre for Eating Disorders, The Ottawa Hospital, ON, Canada.
European Eating Disorders Review (Impact Factor: 2.46). 03/2012; 20(2):155-61. DOI: 10.1002/erv.1133
Source: PubMed


This study aimed to identify predictors of acceptance of intensive treatment and of participation in a randomized controlled trial (RCT) among women with anorexia nervosa (AN).
Participant data were drawn from a tertiary care intensive treatment programme including a previously published RCT. Women with AN (N = 106) were offered intensive treatment, and 69 were approached to participate in an RCT of olanzapine's efficacy as an adjunctive treatment for AN. AN subtype and pretreatment psychological variables were used to predict acceptance of intensive treatment and RCT participation.
AN binge purge subtype and higher depression and body dissatisfaction predicted intensive treatment acceptance. No variable predicted RCT participation among treatment acceptors.
Clinicians may focus on enhancing motivation or use a stepped care approach to increase intensive treatment acceptance especially among women with AN-restricting type and among all those with AN who have lower levels of distress.

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    • "Halmi et al [10] suggest that among people with anorexia nervosa, a high level of obsessive preoccupations, assessed by the Yale-Brown-Cornell Eating Disorder scale, is a predictive factor for the acceptance of care involving cognitive-behavioural therapy, with or without treatment by fluoxetine. Compared with patients with purely restrictive anorexia nervosa, those with bulimic anorexia or purging behaviour may accept in-hospital treatment more easily, according to Tasca et al [11]. The same appears true for patients with depressive symptoms or strong body dissatisfaction, independently of type of anorexia nervosa. "
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