Vol. 23, No. 2, 2011
Received October 11, 2010, Revised January 4, 2011, Accepted for
publication January 4, 2011
Corresponding author: Sook-Ja Son, M.D., Department of Dermatology,
Eulji General Hospital, College of Medicine, Eulji University, 280-1
Hagye 1-dong, Nowon-gu, Seoul 139-711, Korea. Tel: 82-2-970-8280,
Fax: 82-2-974-1577, E-mail: ssjmdderma@ eulji.ac.kr
Ann DermatolVol. 23, No. 2, 2011 DOI: 10.5021/ad.2011.23.2.185
A Clinical and Histopathological Study of 122 Cases of
Dermatofibroma (Benign Fibrous Histiocytoma)
Tae Young Han, M.D., Hee Sun Chang, M.D., June Hyun Kyung Lee, M.D., Won-Mi Lee, M.D.1,
Sook-Ja Son, M.D.
Departments of Dermatology and 1Pathology, Eulji General Hospital, College of Medicine, Eulji University, Seoul, Korea
Background: Many variants of dermatofibromas have been
described, and being aware of the variants of derma-
tofibromas is important to avoid misdiagnosis. Objective:
We wanted to evaluate the clinical and pathologic
characteristics of 122 cases of dermatofibromas. Methods:
We retrospectively reviewed the medical records and 122
biopsy specimens of 92 patients who were diagnosed with
dermatofibroma in the Department of Dermatology at Eulji
Hospital of Eulji University between January 2000 and
March 2010. Results: Nearly 80% of the cases occurred
between the ages of 20 and 49 years, with an overall
predominance of females. Over 70% of the lesions were
found on the extremities. The most common histologic
variant was a fibrocollagenous dermatofibroma (40.1%).
Other variants included histiocytic (13.1%), cellular
(11.5%), aneurysmal (7.4%), angiomatous (6.5%), sclerotic
(6.5%), monster (4.9%), palisading (1.6%) and keloidal
dermatofibromas (0.8%). There were 9 dermatofibromas
(7.3%) that were the mixed type with two co-dominant
histologic features. Conclusion: The results of this study are
consistent with previous reports on the clinical features of
dermatofibromas. However, we observed several characteri-
stic subtypes of dermatofibroma and we compared the
frequency of the histologic subtypes. (Ann Dermatol 23(2)
Dermatofibroma (benign fibrous histiocytoma) is a
common skin lesion and it accounts for approximately 3%
of the skin lesion specimens received by one derma-
topathology laboratory1. There is a predilection for derma-
tofibroma to develop on the extremities, and particularly
on the lower extremities of young adults. There is a female
preponderance amongst the patients with dermatofib-
roma1. Dermatofibroma is round or ovoid, firm, dermal
nodules and they are usually ＜1 cm in diameter2. The
diagnosis is usually straightforward if the classical clinical
and pathologic features are evident. However, many
variants of dermatofibromas have been described, and
knowledge of these variations is important to avoid a
misdiagnosis of a possibly more aggressive tumor. The
main histologic variants include fibrocollagenous, cell-
ular3, histiocytic4, lipidized5, angiomatous6, aneurysmal7,
clear cell8, monster cell9, myxoid10, keloidal11, palisad-
ing12, osteoclastic13 and epithelioid dermatofibroma14.
There are no prior Korean reports regarding the detailed
classification of the histologic features of dermatofib-
romas. Therefore, we report here on a series of 122 cases
of dermatofibroma and we discuss the clinical and
MATERIALS AND METHODS
We performed a retrospective review of the medical
records and 122 biopsy specimens of 92 patients who
were diagnosed with dermatofibroma in the Department
of Dermatology at Eulji Hospital of Eulji University
between January 2000 and March 2010.
The following clinical data was collected: age, gender,
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